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Tbio
IL18BP
Interleukin-18-binding protein

Protein Summary
Description
Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response. The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260049
  • ENSP00000260049
  • ENSG00000137496
  • ENST00000337131
  • ENSP00000338723
  • ENST00000343898
  • ENSP00000343309
  • ENST00000393703
  • ENSP00000377306
  • ENST00000393705
  • ENSP00000377308
  • ENST00000393707
  • ENSP00000377310
  • ENST00000404792
  • ENSP00000384212
  • ENST00000534583
  • ENSP00000434376
  • ENST00000620017
  • ENSP00000480621

Symbol
  • IL18BPa
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.9
gene perturbation
0.76
kinase perturbation
0.66
tissue sample
0.62
cell line
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.35   (req: < 5)
Gene RIFs: 40   (req: <= 3)
Antibodies: 417   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.35   (req: >= 5)
Gene RIFs: 40   (req: > 3)
Antibodies: 417   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (28)
IL18
Tbio
Novelty:  0.00022844
Score:  0.994
Data Source:  Reactome,STRINGDB
IL37
Tbio
Novelty:  0.00499186
Score:  0.986
Data Source:  Reactome,STRINGDB
IL18RAP
Tbio
Novelty:  0.0141773
Score:  0.956
Data Source:  STRINGDB
IL18R1
Tbio
Novelty:  0.01634385
Score:  0.954
Data Source:  STRINGDB
IFNG
Tclin
Novelty:  0.00009731
Score:  0.652
Data Source:  STRINGDB
CASP1
Tchem
Family:  Enzyme
Novelty:  0.00034643
Score:  0.61
Data Source:  STRINGDB
STAT1
Tchem
Family:  TF
Novelty:  0.0003383
Score:  0.596
Data Source:  STRINGDB
IL4
Tbio
Novelty:  0.00005852
Score:  0.581
Data Source:  STRINGDB
IL1RAP
Tclin
Novelty:  0.01115915
Score:  0.51
Data Source:  STRINGDB
IRF8
Tbio
Family:  TF
Novelty:  0.00330143
Score:  0.5
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-1 family signaling
Reactome
Interleukin-18 signaling
Reactome
Interleukin-37 signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-1 family signaling
Interleukin-18 signaling
Interleukin-37 signaling
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
1
1
7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interleukin 18 binding protein
VGNC:1068
748234
Macaque
interleukin 18 binding protein
100144607
Mouse
MGI:1333800
16068
Rat
RGD:620042
84388
Dog
interleukin 18 binding protein
VGNC:41952
476818
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interleukin 18 binding protein
Macaque
interleukin 18 binding protein
Mouse
Rat
Dog
interleukin 18 binding protein
Publication Statistics
PubMed Score 123.35
PubMed score by year
PubTator Score 74.04
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title