You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
IL18BP
Interleukin-18-binding protein

Protein Summary
Description
Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response. The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260049
  • ENSP00000260049
  • ENSG00000137496
  • ENST00000337131
  • ENSP00000338723
  • ENST00000343898
  • ENSP00000343309
  • ENST00000393703
  • ENSP00000377306
  • ENST00000393705
  • ENSP00000377308
  • ENST00000393707
  • ENSP00000377310
  • ENST00000404792
  • ENSP00000384212
  • ENST00000534583
  • ENSP00000434376
  • ENST00000620017
  • ENSP00000480621

Symbol
  • IL18BPa
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.9
gene perturbation
0.76
kinase perturbation
0.66
tissue sample
0.62
cell line
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 135.34   (req: < 5)
Gene RIFs: 40   (req: <= 3)
Antibodies: 417   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 135.34   (req: >= 5)
Gene RIFs: 40   (req: > 3)
Antibodies: 417   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0