Protein Summary
A proinflammatory cytokine primarily involved in polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses (Probable). Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators (PubMed:14528293, PubMed:25500532). Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells (Probable) (PubMed:10653850). The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011]
- ENST00000280357
- ENSP00000280357
- ENSG00000150782
- ENST00000524595
- ENSP00000434561
- ENST00000528832
- ENSP00000434161
- IGIF
- IL1F4
- IGIF
- IL-18
- IL-1g
- IL1F4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 1 | ||
biological process | 0.99 | ||
gene perturbation | 0.96 | ||
chemical | 0.95 | ||
PubMedID | 0.91 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4678.04 (req: < 5)
Gene RIFs: 825 (req: <= 3)
Antibodies: 794 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4678.04 (req: >= 5)
Gene RIFs: 825 (req: > 3)
Antibodies: 794 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 49
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (354)
TDGF1
Novelty: 0.00527099
p_int: 0.999090533
p_ni: 0.00089975
p_wrong: 0.000009716
Score: 0.189
Data Source: BioPlex,STRINGDB
CDK15
Family: Kinase
Novelty: 0.3870338
p_int: 0.858373794
p_ni: 0.140554266
p_wrong: 0.00107194
Score: 0.159
Data Source: BioPlex,STRINGDB
ZNF747
Novelty: 9
p_int: 0.822168297
p_ni: 0.177571059
p_wrong: 0.000260644
Score: 0.232
Data Source: BioPlex,STRINGDB
SERPINB4
Novelty: 0.00522283
p_int: 0.807189266
p_ni: 0.192810734
Score: 0.331
Data Source: BioPlex,STRINGDB
FAM24B
Novelty: 1.04675689
p_int: 0.761237371
p_ni: 0.005851989
p_wrong: 0.23291064
Data Source: BioPlex
Nearest Tclin Targets (4)
Upstream (1)
Downstream (3)
1 – 1 of 1
Pathways (41)
Reactome (8)
KEGG (13)
PathwayCommons (12)
WikiPathways (8)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Immune System | ||||
Reactome | Interleukin-1 family signaling | ||||
Reactome | Interleukin-1 processing | ||||
Reactome | Interleukin-10 signaling | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cytokine Signaling in Immune system | ||||
Immune System | ||||
Interleukin-1 family signaling | ||||
Interleukin-1 processing | ||||
Interleukin-10 signaling | ||||
Viral Interactions (0)
Gene Ontology Terms (52)
Functions (2)
Components (3)
Processes (47)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Disease Associations ()
GWAS Traits (13)
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
interleukin 18 measurement | 3 | 3 | 3 | 98.1 | |||||
blood protein measurement | 1 | 1 | 1 | 80.8 | |||||
interleukin 1 receptor antagonist measurement | 1 | 1 | 1 | 80.5 | |||||
interleukin-1 beta measurement | 1 | 1 | 1 | 80.5 | |||||
heel bone mineral density | 1 | 1 | 1 | 70.2 | |||||
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
interleukin 18 measurement | 3 | 98.1 | |||||
blood protein measurement | 1 | 80.8 | |||||
interleukin 1 receptor antagonist measurement | 1 | 80.5 | |||||
interleukin-1 beta measurement | 1 | 80.5 | |||||
heel bone mineral density | 1 | 70.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | interleukin 18 | VGNC:1069 | 739011 | |||||
Mouse | MGI:107936 | 16173 | ||||||
Rat | RGD:2889 | 29197 | ||||||
Dog | interleukin 18 | VGNC:41951 | 403796 | |||||
Horse | interleukin 18 | VGNC:19006 | 100034216 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | interleukin 18 | |||||
Mouse | ||||||
Rat | ||||||
Dog | interleukin 18 | |||||
Horse | interleukin 18 | |||||
Publication Statistics
PubMed Score 4678.04
PubMed score by year
PubTator Score 2301.68
PubTator score by year
Related Publications
Text Mined References (937)
GeneRif Annotations (825)
Items per page:
0 of 0
PMID | Year | Title |
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