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Tbio
IL18
Interleukin-18

Protein Summary
Description
A proinflammatory cytokine primarily involved in polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses (Probable). Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators (PubMed:14528293, PubMed:25500532). Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells (Probable) (PubMed:10653850). The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000280357
  • ENSP00000280357
  • ENSG00000150782
  • ENST00000524595
  • ENSP00000434561
  • ENST00000528832
  • ENSP00000434161

Symbol
  • IGIF
  • IL1F4
  • IGIF
  • IL-18
  • IL-1g
  • IL1F4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
biological process
0.99
gene perturbation
0.96
chemical
0.95
PubMedID
0.91


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4678.04   (req: < 5)
Gene RIFs: 825   (req: <= 3)
Antibodies: 794   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4678.04   (req: >= 5)
Gene RIFs: 825   (req: > 3)
Antibodies: 794   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 49
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (354)
TDGF1
Tbio
Novelty:  0.00527099
p_int:  0.999090533
p_ni:  0.00089975
p_wrong:  0.000009716
Score:  0.189
Data Source:  BioPlex,STRINGDB
WASHC3
Tdark
Novelty:  0.18307321
p_int:  0.967208626
p_ni:  0.032791374
Data Source:  BioPlex
CDK15
Tchem
Family:  Kinase
Novelty:  0.3870338
p_int:  0.858373794
p_ni:  0.140554266
p_wrong:  0.00107194
Score:  0.159
Data Source:  BioPlex,STRINGDB
ZNF747
Tdark
Novelty:  9
p_int:  0.822168297
p_ni:  0.177571059
p_wrong:  0.000260644
Score:  0.232
Data Source:  BioPlex,STRINGDB
SERPINB4
Tbio
Novelty:  0.00522283
p_int:  0.807189266
p_ni:  0.192810734
Score:  0.331
Data Source:  BioPlex,STRINGDB
FAM24B
Tdark
Novelty:  1.04675689
p_int:  0.761237371
p_ni:  0.005851989
p_wrong:  0.23291064
Data Source:  BioPlex
CASP1
Tchem
Family:  Enzyme
Novelty:  0.00034643
Score:  0.998
Data Source:  Reactome,STRINGDB
IL18RAP
Tbio
Novelty:  0.0141773
Score:  0.997
Data Source:  Reactome,STRINGDB
IL18R1
Tbio
Novelty:  0.01634385
Score:  0.995
Data Source:  Reactome,STRINGDB
IL18BP
Tbio
Novelty:  0.00838895
Score:  0.994
Data Source:  Reactome,STRINGDB
Pathways (41)
Cytokine Signaling in Immune system (R-HSA-1280215)

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Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-1 family signaling
Reactome
Interleukin-1 processing
Reactome
Interleukin-10 signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-1 family signaling
Interleukin-1 processing
Interleukin-10 signaling
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
interleukin 18 measurement
3
3
3
98.1
blood protein measurement
1
1
1
80.8
interleukin 1 receptor antagonist measurement
1
1
1
80.5
interleukin-1 beta measurement
1
1
1
80.5
heel bone mineral density
1
1
1
70.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
interleukin 18 measurement
3
98.1
blood protein measurement
1
80.8
interleukin 1 receptor antagonist measurement
1
80.5
interleukin-1 beta measurement
1
80.5
heel bone mineral density
1
70.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interleukin 18
VGNC:1069
739011
Mouse
MGI:107936
16173
Rat
RGD:2889
29197
Dog
interleukin 18
VGNC:41951
403796
Horse
interleukin 18
VGNC:19006
100034216
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interleukin 18
Mouse
Rat
Dog
interleukin 18
Horse
interleukin 18
Publication Statistics
PubMed Score 4678.04
PubMed score by year
PubTator Score 2301.68
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title