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Tclin
IL17RC
Interleukin-17 receptor C

Protein Summary
Description
Receptor for IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RA (PubMed:16785495). Receptor for the heterodimer formed by IL17A and IL17B as part of a heterodimeric complex with IL17RA (PubMed:18684971). Has also been shown to be the cognate receptor for IL17F and to bind IL17A with high affinity without the need for IL17RA (PubMed:17911633). Activation of IL17RC leads to induction of expression of inflammatory chemokines and cytokines such as CXCL1 (PubMed:16785495). Isoform 5: Receptor for both IL17A and IL17F. Isoform 6: Does not bind IL17A or IL17F. Isoform 7: Does not bind IL17A or IL17F. Isoform 8: Receptor for both IL17A and IL17F. This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295981
  • ENSP00000295981
  • ENSG00000163702
  • ENST00000383812
  • ENSP00000373323
  • ENST00000403601
  • ENSP00000384969
  • ENST00000413608
  • ENSP00000396064
  • ENST00000416074
  • ENSP00000395315
  • ENST00000455057
  • ENSP00000407894
  • ENST00000648140
  • ENSP00000497825

Symbol
  • CANDF9
  • IL17RL
  • IL17-RL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.62
kinase perturbation
0.6
histone modification site profile
0.56
tissue
0.56
tissue sample
0.52


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.31   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 304   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.31   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 304   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (86)
ATP2A3
Tchem
Family:  Transporter
Novelty:  0.0090982
p_int:  0.999643244
p_ni:  0.000356756
Data Source:  BioPlex
KCNT2
Tchem
Family:  IC
Novelty:  0.02412039
p_int:  0.999609638
p_ni:  0.000390362
Data Source:  BioPlex
KCNJ11
Tclin
Family:  IC
Novelty:  0.00068183
p_int:  0.999503796
p_ni:  0.000483825
p_wrong:  0.000012379
Data Source:  BioPlex
GMCL1
Tbio
Novelty:  0.1543762
p_int:  0.999131393
p_ni:  0.000868597
p_wrong:  1e-8
Data Source:  BioPlex
DHRS3
Tbio
Family:  Enzyme
Novelty:  0.04448013
p_int:  0.998239718
p_ni:  0.000817257
p_wrong:  0.000943025
Data Source:  BioPlex
ADCK2
Tbio
Family:  Kinase
Novelty:  0.13237052
p_int:  0.9936562
p_ni:  0.006337423
p_wrong:  0.000006377
Data Source:  BioPlex
PIGQ
Tbio
Family:  Enzyme
Novelty:  0.02701629
p_int:  0.993526603
p_ni:  0.006406948
p_wrong:  0.000066449
Score:  0.157
Data Source:  BioPlex,STRINGDB
SLC12A4
Tbio
Family:  Transporter
Novelty:  0.01077688
p_int:  0.993104668
p_ni:  0.006895332
Data Source:  BioPlex
LRP12
Tbio
Novelty:  0.11426952
p_int:  0.991370954
p_ni:  0.008628923
p_wrong:  1.23e-7
Data Source:  BioPlex
ADCY3
Tbio
Family:  Enzyme
Novelty:  0.00260265
p_int:  0.989974863
p_ni:  0.010023416
p_wrong:  0.00000172
Score:  0.172
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-17 signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-17 signaling
Signaling by Interleukins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
40.6
body mass index
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
40.6
body mass index
1
31.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interleukin 17 receptor C
VGNC:1845
460159
Mouse
MGI:2159336
171095
Rat
RGD:1306392
297520
Dog
interleukin 17 receptor C
VGNC:41948
610118
Horse
interleukin 17 receptor C
VGNC:19004
100058271
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interleukin 17 receptor C
Mouse
Rat
Dog
interleukin 17 receptor C
Horse
interleukin 17 receptor C
Publication Statistics
PubMed Score 43.31
PubMed score by year
PubTator Score 33.69
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title