Tclin IL17RC Interleukin-17 receptor C

Protein Summary

Description

Receptor for IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RA (PubMed:16785495). Receptor for the heterodimer formed by IL17A and IL17B as part of a heterodimeric complex with IL17RA (PubMed:18684971). Has also been shown to be the cognate receptor for IL17F and to bind IL17A with high affinity without the need for IL17RA (PubMed:17911633). Activation of IL17RC leads to induction of expression of inflammatory chemokines and cytokines such as CXCL1 (PubMed:16785495). Isoform 5: Receptor for both IL17A and IL17F. Isoform 6: Does not bind IL17A or IL17F. Isoform 7: Does not bind IL17A or IL17F. Isoform 8: Receptor for both IL17A and IL17F. This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling. [provided by RefSeq, Feb 2011]

Uniprot Accession IDs

• Q8NAC3
• A8BWC1
• A8BWC9
• A8BWD5
• E9PHG1
• E9PHJ6
• Q6UVY3
• Q6UWD4
• Q8NFS1
• Q9BR97
• IL-17 receptor C

Gene Name

• IL17RC

Ensembl ID

• ENST00000295981
• ENSP00000295981
• ENSG00000163702
• ENST00000383812
• ENSP00000373323
• ENST00000403601
• ENSP00000384969
• ENST00000413608
• ENSP00000396064
• ENST00000416074
• ENSP00000395315
• ENST00000455057
• ENSP00000407894
• ENST00000648140
• ENSP00000497825

Symbol

• CANDF9
• IL17RL
• IL17-RL

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell line	0.62
kinase perturbation	0.6
histone modification site profile	0.56
tissue	0.56
tissue sample	0.52

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.56   (req: < 5)

Gene RIFs: 23   (req: <= 3)

Antibodies: 304   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.56   (req: >= 5)

Gene RIFs: 23   (req: > 3)

Antibodies: 304   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1