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Tbio
IL17RB
Interleukin-17 receptor B

Protein Summary
Description
Receptor for the proinflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells. The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E, but does not bind to IL17 and IL17C. This receptor has been shown to mediate the activation of NF-kappaB and the production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000288167
  • ENSP00000288167
  • ENSG00000056736

Symbol
  • CRL4
  • EVI27
  • IL17BR
  • CRL4
  • EVI27
  • IL17BR
  • IL17RH1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.84
PubMedID
0.76
histone modification site profile
0.64
small molecule perturbation
0.61
cell type or tissue
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.59   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 412   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.59   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 412   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (65)
SELENOO
Tdark
Novelty:  0.02959704
p_int:  0.999959617
p_ni:  0.000040381
p_wrong:  2e-9
Data Source:  BioPlex
RNFT1
Tdark
Novelty:  1.15288082
p_int:  0.999703018
p_ni:  0.000009179
p_wrong:  0.000287803
Score:  0.219
Data Source:  BioPlex,STRINGDB
TMEM63B
Tdark
Family:  IC
Novelty:  0.25017412
p_int:  0.996219971
p_ni:  0.003779971
p_wrong:  5.9e-8
Data Source:  BioPlex
PIGQ
Tbio
Family:  Enzyme
Novelty:  0.02701629
p_int:  0.993526603
p_ni:  0.006406948
p_wrong:  0.000066449
Data Source:  BioPlex
ATP2A3
Tchem
Family:  Transporter
Novelty:  0.0090982
p_int:  0.990074779
p_ni:  0.00992522
p_wrong:  1e-9
Data Source:  BioPlex
BMPR1A
Tchem
Family:  Kinase
Novelty:  0.00343928
p_int:  0.988038657
p_ni:  0.011961342
Data Source:  BioPlex
STIM1
Tbio
Novelty:  0.00116516
p_int:  0.976942887
p_ni:  0.023057113
Score:  0.181
Data Source:  BioPlex,STRINGDB
RETSAT
Tdark
Family:  Enzyme
Novelty:  0.10624626
p_int:  0.974393835
p_ni:  0.025606165
Data Source:  BioPlex
ST7L
Tbio
Novelty:  0.03661324
p_int:  0.973778465
p_ni:  0.026219654
p_wrong:  0.00000188
Data Source:  BioPlex
RHOBTB3
Tbio
Novelty:  0.09149494
p_int:  0.943446627
p_ni:  0.049474591
p_wrong:  0.007078782
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Cytokine Signaling in Immune system (R-HSA-1280215)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-17 signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-17 signaling
Signaling by Interleukins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
interleukin 17 receptor B measurement
1
1
1
87.9
testosterone measurement
2
2
2
75.9
refractive error
2
2
1
6.5
68.9
body mass index
2
1
2
64.4
systolic blood pressure
1
1
1
55.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
interleukin 17 receptor B measurement
1
87.9
testosterone measurement
2
75.9
refractive error
1
6.5
68.9
body mass index
2
64.4
systolic blood pressure
1
55.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interleukin 17 receptor B
VGNC:1844
460451
Macaque
interleukin 17 receptor B
693671
Mouse
MGI:1355292
50905
Rat
RGD:1311392
306247
Dog
interleukin 17 receptor B
VGNC:41947
476587
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interleukin 17 receptor B
Macaque
interleukin 17 receptor B
Mouse
Rat
Dog
interleukin 17 receptor B
Publication Statistics
PubMed Score 77.59
PubMed score by year
PubTator Score 100.30
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title