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Tclin
IL17F
Interleukin-17F

Protein Summary
Description
Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in stimulating the production of other cytokines such as IL6, IL8 and CSF2, and in regulation of cartilage matrix turnover (PubMed:11591732, PubMed:11591768, PubMed:11574464). Also involved in stimulating the proliferation of peripheral blood mononuclear cells and T-cells and in inhibition of angiogenesis (PubMed:11591732). Plays a role in the induction of neutrophilia in the lungs and in the exacerbation of antigen-induced pulmonary allergic inflammation (By similarity). The protein encoded by this gene is a cytokine that shares sequence similarity with IL17. This cytokine is expressed by activated T cells, and has been shown to stimulate the production of several other cytokines, including IL6, IL8, and CSF2/GM_CSF. This cytokine is also found to inhibit the angiogenesis of endothelial cells and ind ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336123
  • ENSP00000337432
  • ENSG00000112116

Symbol
  • ML1
  • ML-1
  • CANDF6
  • IL-17F
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.75
biological process
0.74
trait
0.61
disease
0.49
phenotype
0.49


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 425.78   (req: < 5)
Gene RIFs: 168   (req: <= 3)
Antibodies: 776   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 425.78   (req: >= 5)
Gene RIFs: 168   (req: > 3)
Antibodies: 776   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (142)
VCAN
Tbio
Novelty:  0.00110986
p_int:  0.999991361
p_ni:  0.000008633
p_wrong:  6e-9
Data Source:  BioPlex
TMEM159
Tdark
Novelty:  0.22237677
p_int:  0.998757455
p_ni:  0.00023319
p_wrong:  0.001009355
Data Source:  BioPlex
HMGCS1
Tchem
Family:  Enzyme
Novelty:  0.01089288
p_int:  0.998571666
p_ni:  0.001426859
p_wrong:  0.000001475
Data Source:  BioPlex
MCRIP2
Tdark
Novelty:  1.50465727
p_int:  0.998503522
p_ni:  0.001318874
p_wrong:  0.000177604
Data Source:  BioPlex
C20orf141
Tdark
Novelty:  7
p_int:  0.998503522
p_ni:  0.001318874
p_wrong:  0.000177604
Data Source:  BioPlex
SDHD
Tbio
Family:  Enzyme
Novelty:  0.00167904
p_int:  0.998047936
p_ni:  0.00139865
p_wrong:  0.000553414
Data Source:  BioPlex
PRKCI
Tchem
Family:  Kinase
Novelty:  0.0076377
p_int:  0.997190479
p_ni:  0.00280952
p_wrong:  1e-9
Data Source:  BioPlex
VWDE
Tdark
Novelty:  0.37298162
p_int:  0.99625355
p_ni:  0.003447228
p_wrong:  0.000299221
Data Source:  BioPlex
C1GALT1C1
Tbio
Family:  Enzyme
Novelty:  0.01318017
p_int:  0.994814556
p_ni:  0.005185444
Data Source:  BioPlex
SQSTM1
Tbio
Novelty:  0.00100555
p_int:  0.94672289
p_ni:  0.05327711
Data Source:  BioPlex
Pathways (53)
Cytokine Signaling in Immune system (R-HSA-1280215)

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Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-17 signaling
Reactome
Interleukin-4 and Interleukin-13 signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-17 signaling
Interleukin-4 and Interleukin-13 signaling
Signaling by Interleukins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
response to gemcitabine
1
1
0
3.3
46.7
1
1
0
3.3
36.9
overall survival
1
1
0
3.3
36.9
mean platelet volume
1
1
1
3.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
response to gemcitabine
0
3.3
46.7
0
3.3
36.9
overall survival
0
3.3
36.9
mean platelet volume
1
3.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interleukin 17F
VGNC:3124
472030
Macaque
interleukin 17F
708220
Mouse
MGI:2676631
257630
Rat
RGD:1311398
301291
Dog
interleukin 17F
VGNC:41945
481838
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interleukin 17F
Macaque
interleukin 17F
Mouse
Rat
Dog
interleukin 17F
Publication Statistics
PubMed Score 425.78
PubMed score by year
PubTator Score 970.42
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title