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Tbio
IL17C
Interleukin-17C

Protein Summary
Description
Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases. The protein encoded by this gene is a T cell-derived cytokine that shares the sequence similarity with IL17. This cytokine was reported to stimulate the release of tumor necrosis factor alpha and inte ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000244241
  • ENSP00000244241
  • ENSG00000124391

Symbol
  • CX2
  • IL-17C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.56
phenotype
0.52
disease
0.5
cell line
0.46
transcription factor
0.46


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 207.35   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 293   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 207.35   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 293   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (29)
IL17RE
Tbio
Novelty:  0.07568341
Score:  0.989
Data Source:  Reactome,STRINGDB
IL17RA
Tclin
Novelty:  0.00416706
Score:  0.989
Data Source:  Reactome,STRINGDB
IL17RB
Tbio
Novelty:  0.01540031
Score:  0.812
Data Source:  STRINGDB
IL17RC
Tclin
Novelty:  0.01844832
Score:  0.766
Data Source:  STRINGDB
IL17RD
Tbio
Novelty:  0.02157815
Score:  0.689
Data Source:  STRINGDB
IL13
Tbio
Novelty:  0.00021435
Score:  0.632
Data Source:  STRINGDB
FOXP3
Tbio
Family:  TF
Novelty:  0.00017205
Score:  0.577
Data Source:  STRINGDB
CCL11
Tbio
Novelty:  0.00086805
Score:  0.539
Data Source:  STRINGDB
CCL20
Tbio
Novelty:  0.00158263
Score:  0.538
Data Source:  STRINGDB
XPR1
Tbio
Novelty:  0.00735578
Score:  0.53
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-17 signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-17 signaling
Signaling by Interleukins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Disease Associations (null)
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
3
5
5
98.2
reticulocyte count
5
6
12
96.4
hemoglobin measurement
2
5
5
94.3
reticulocyte measurement
3
4
7
93.6
mean corpuscular hemoglobin concentration
1
2
2
89.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
5
98.2
reticulocyte count
12
96.4
hemoglobin measurement
5
94.3
reticulocyte measurement
7
93.6
mean corpuscular hemoglobin concentration
2
89.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interleukin 17C
VGNC:5807
468067
Mouse
MGI:2446486
234836
Rat
RGD:1582798
691516
Dog
interleukin 17C
VGNC:41944
608988
Horse
interleukin 17C [Source:HGNC Symbol;Acc:HGNC:5983]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interleukin 17C
Mouse
Rat
Dog
interleukin 17C
Horse
interleukin 17C [Source:HGNC Symbol;Acc:HGNC:5983]
Publication Statistics
PubMed Score 207.35
PubMed score by year
PubTator Score 57.22
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title