Protein Summary
Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1. The protein encoded by this gene is a T cell-derived cytokine that shares sequence similarity with IL17. This cytokine was reported to stimulate the release of TNF alpha (TNF) and IL1 beta (IL1B) from a monocytic cell line. Immunohistochemical analysis of several nerve tissues indicated that this cytokine is primarily localized to neuronal cell bodies. Alternative splicing results in multiple splice variants. [provided by RefSeq, Dec 2015]
- ENST00000261796
- ENSP00000261796
- ENSG00000127743
- IL20
- NIRF
- ZCYTO7
- NIRF
- IL-20
- IL-17B
- ZCYTO7
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
gene perturbation | 0.76 | ||
virus perturbation | 0.64 | ||
cell type or tissue | 0.63 | ||
PubMedID | 0.6 | ||
chemical | 0.41 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 32.62 (req: < 5)
Gene RIFs: 15 (req: <= 3)
Antibodies: 400 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 32.62 (req: >= 5)
Gene RIFs: 15 (req: > 3)
Antibodies: 400 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0