Tbio IL17B Interleukin-17B

Protein Summary

Description

Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1. The protein encoded by this gene is a T cell-derived cytokine that shares sequence similarity with IL17. This cytokine was reported to stimulate the release of TNF alpha (TNF) and IL1 beta (IL1B) from a monocytic cell line. Immunohistochemical analysis of several nerve tissues indicated that this cytokine is primarily localized to neuronal cell bodies. Alternative splicing results in multiple splice variants. [provided by RefSeq, Dec 2015]

Uniprot Accession IDs

• Q9UHF5
• Q14CE5
• IL-17B

Gene Name

• IL17B

Ensembl ID

• ENST00000261796
• ENSP00000261796
• ENSG00000127743

Symbol

• IL20
• NIRF
• ZCYTO7
• NIRF
• IL-20
• IL-17B
• ZCYTO7

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.76
virus perturbation	0.64
cell type or tissue	0.63
PubMedID	0.6
chemical	0.41

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.62   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 400   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.62   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 400   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0