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Tbio
IL17B
Interleukin-17B

Protein Summary
Description
Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1. The protein encoded by this gene is a T cell-derived cytokine that shares sequence similarity with IL17. This cytokine was reported to stimulate the release of TNF alpha (TNF) and IL1 beta (IL1B) from a monocytic cell line. Immunohistochemical analysis of several nerve tissues indicated that this cytokine is primarily localized to neuronal cell bodies. Alternative splicing results in multiple splice variants. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261796
  • ENSP00000261796
  • ENSG00000127743

Symbol
  • IL20
  • NIRF
  • ZCYTO7
  • NIRF
  • IL-20
  • IL-17B
  • ZCYTO7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.76
virus perturbation
0.64
cell type or tissue
0.63
PubMedID
0.6
chemical
0.41


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.62   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 400   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.62   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 400   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (45)
DPH2
Tbio
Novelty:  0.04268301
p_int:  0.999995572
p_ni:  0.000004428
Data Source:  BioPlex
HIST1H1C
Tbio
Novelty:  0.00415337
p_int:  0.999839163
p_ni:  0.000160837
Data Source:  BioPlex
KBTBD7
Tbio
Novelty:  0.4947466
p_int:  0.999582397
p_ni:  0.000417603
Data Source:  BioPlex
ERBIN
Tbio
Novelty:  0.01419561
p_int:  0.99875709
p_ni:  0.00124291
Data Source:  BioPlex
DPH1
Tbio
Novelty:  0.02296024
p_int:  0.998665493
p_ni:  0.001332996
p_wrong:  0.000001512
Data Source:  BioPlex
TTL
Tchem
Family:  Enzyme
Novelty:  0.03494724
p_int:  0.99381464
p_ni:  0.006170764
p_wrong:  0.000014595
Data Source:  BioPlex
MYEF2
Tbio
Novelty:  0.33569061
p_int:  0.971722844
p_ni:  0.028277156
Data Source:  BioPlex
STAU1
Tbio
Novelty:  0.00565778
p_int:  0.961249743
p_ni:  0.038750257
Data Source:  BioPlex
RSPRY1
Tdark
Novelty:  0.26883105
p_int:  0.960639537
p_ni:  0.039360448
p_wrong:  1.5e-8
Data Source:  BioPlex
RBM28
Tbio
Novelty:  0.13090674
p_int:  0.949567974
p_ni:  0.050432026
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
1
4
89.2
brain measurement
1
1
0
13.2
72.9
forced expiratory volume
1
1
1
65.5
cortical thickness
1
1
0
7.6
51
cortical surface area measurement
1
1
0
7.6
51
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
4
89.2
brain measurement
0
13.2
72.9
forced expiratory volume
1
65.5
cortical thickness
0
7.6
51
cortical surface area measurement
0
7.6
51
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interleukin 17B
VGNC:4043
741839
Macaque
interleukin 17B [Source:HGNC Symbol;Acc:HGNC:5982]
Mouse
MGI:1928397
56069
Rat
RGD:620614
116472
Dog
interleukin 17B
VGNC:41943
489193
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interleukin 17B
Macaque
interleukin 17B [Source:HGNC Symbol;Acc:HGNC:5982]
Mouse
Rat
Dog
interleukin 17B
Publication Statistics
PubMed Score 32.62
PubMed score by year
PubTator Score 46.16
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title