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Tbio
IL16
Pro-interleukin-16

Protein Summary
Description
Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. Isoform 1 may act as a scaffolding protein that anchors ion channels in the membrane. Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells. The protein encoded by this gene is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of this cytokine is mediated by CD4. The product of this gene unde ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302987
  • ENSP00000302935
  • ENSG00000172349
  • ENST00000394652
  • ENSP00000378147
  • ENST00000394660
  • ENSP00000378155

Symbol
  • LCF
  • NIL16
  • PRIL16
  • prIL-16
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.99
hub protein
0.71
disease
0.7
cell line
0.63
tissue sample
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1005.97   (req: < 5)
Gene RIFs: 109   (req: <= 3)
Antibodies: 697   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1005.97   (req: >= 5)
Gene RIFs: 109   (req: > 3)
Antibodies: 697   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (118)
RNF169
Tbio
Family:  Enzyme
Novelty:  0.28921437
p_int:  0.999882708
p_ni:  0.000113149
p_wrong:  0.000004143
Score:  0.416
Data Source:  BioPlex,STRINGDB
NRBP2
Tbio
Family:  Kinase
Novelty:  0.28776838
p_int:  0.997773828
p_ni:  0.000181919
p_wrong:  0.002044252
Score:  0.416
Data Source:  BioPlex,STRINGDB
NPB
Tdark
Novelty:  0.00936692
p_int:  0.997713513
p_ni:  0.000259679
p_wrong:  0.002026808
Score:  0.161
Data Source:  BioPlex,STRINGDB
ZNF148
Tbio
Family:  TF
Novelty:  0.01613534
p_int:  0.995038981
p_ni:  8.48e-7
p_wrong:  0.004960171
Score:  0.692
Data Source:  BioPlex,STRINGDB
CAMK1
Tchem
Family:  Kinase
Novelty:  0.01239891
p_int:  0.908098576
p_ni:  0.091901424
Score:  0.241
Data Source:  BioPlex,STRINGDB
CD4
Tclin
Novelty:  0.00001217
Score:  0.969
Data Source:  Reactome,STRINGDB
CASP3
Tchem
Family:  Enzyme
Novelty:  0.00003555
Score:  0.956
Data Source:  Reactome,STRINGDB
CCL11
Tbio
Novelty:  0.00086805
Score:  0.688
Data Source:  STRINGDB
CCL5
Tchem
Novelty:  0.00032607
Score:  0.687
Data Source:  STRINGDB
IL15
Tchem
Novelty:  0.00049351
Score:  0.683
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (12)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Other interleukin signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Other interleukin signaling
Signaling by Interleukins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
2
2
0
1.1
94.9
interleukin 16 measurement
3
3
3
94.8
pro‐interleukin‐16 measurement
1
2
2
93.8
blood protein measurement
1
1
1
90.8
lymphocyte count
3
1
3
62.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
0
1.1
94.9
interleukin 16 measurement
3
94.8
pro‐interleukin‐16 measurement
2
93.8
blood protein measurement
1
90.8
lymphocyte count
3
62.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interleukin 16
VGNC:1926
449644
Macaque
interleukin 16
574100
Mouse
MGI:1270855
16170
Rat
RGD:1583872
116996
Dog
interleukin 16
VGNC:41941
488762
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interleukin 16
Macaque
interleukin 16
Mouse
Rat
Dog
interleukin 16
Publication Statistics
PubMed Score 1005.97
PubMed score by year
PubTator Score 293.54
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title