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Tchem
IL15
Interleukin-15

Protein Summary
Description
Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha. The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thu ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296545
  • ENSP00000296545
  • ENSG00000164136
  • ENST00000320650
  • ENSP00000323505
  • ENST00000394159
  • ENSP00000377714
  • ENST00000477265
  • ENSP00000436914
  • ENST00000514653
  • ENSP00000422271
  • ENST00000529613
  • ENSP00000435462

Symbol
  • IL-15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
PubMedID
0.86
transcription factor perturbation
0.84
histone modification site profile
0.81


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2470.25   (req: < 5)
Gene RIFs: 346   (req: <= 3)
Antibodies: 1013   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2470.25   (req: >= 5)
Gene RIFs: 346   (req: > 3)
Antibodies: 1013   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (375)
GAPDHS
Tbio
Family:  Enzyme
Novelty:  0.00885959
p_int:  0.993917198
p_ni:  0.005535827
p_wrong:  0.000546975
Data Source:  BioPlex
COL14A1
Tbio
Novelty:  0.01760399
p_int:  0.959076426
p_ni:  0.040923346
p_wrong:  2.28e-7
Data Source:  BioPlex
LRIG1
Tbio
Novelty:  0.01078663
p_int:  0.83812439
p_ni:  0.16187561
Data Source:  BioPlex
PLXNA3
Tbio
Novelty:  0.02016528
p_int:  0.775124923
p_ni:  0.224875077
Data Source:  BioPlex
ITGA7
Tbio
Novelty:  0.01243073
p_int:  0.768523426
p_ni:  0.230504958
p_wrong:  0.000971615
Data Source:  BioPlex
ERO1B
Tbio
Novelty:  0.06389159
p_int:  0.767124221
p_ni:  0.071652037
p_wrong:  0.161223742
Data Source:  BioPlex
IL2RB
Tclin
Novelty:  0.0050905
Score:  0.998
Data Source:  Reactome,STRINGDB
IL15RA
Tbio
Novelty:  0.03493607
Score:  0.997
Data Source:  Reactome,STRINGDB
IL2RG
Tclin
Novelty:  0.00108272
Score:  0.996
Data Source:  Reactome,STRINGDB
STAT5A
Tchem
Family:  TF
Novelty:  0.00074026
Score:  0.982
Data Source:  STRINGDB
Nearest Tclin Targets (17)
Explore Nearest Tclin Targets
Pathways (23)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-15 signaling
Reactome
Interleukin-2 family signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-15 signaling
Interleukin-2 family signaling
Signaling by Interleukins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
1
1
1
18
leukocyte count
1
1
1
12.1
t-tau measurement
1
1
1
9.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
1
18
leukocyte count
1
12.1
t-tau measurement
1
9.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interleukin 15
VGNC:753
737808
Macaque
interleukin 15
699616
Mouse
MGI:103014
16168
Rat
RGD:2887
25670
Dog
interleukin 15
VGNC:41939
403584
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interleukin 15
Macaque
interleukin 15
Mouse
Rat
Dog
interleukin 15
Publication Statistics
PubMed Score 2470.25
PubMed score by year
PubTator Score 1149.65
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title