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Tclin
IL12B
Interleukin-12 subunit beta

Protein Summary
Description
Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000231228
  • ENSP00000231228
  • ENSG00000113302

Symbol
  • NKSF2
  • CLMF
  • NKSF
  • CLMF2
  • IMD28
  • IMD29
  • NKSF2
  • IL-12B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
chemical
1
biological term
0.99
protein domain
0.92
molecular function
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.91   (req: < 5)
Gene RIFs: 346   (req: <= 3)
Antibodies: 859   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.91   (req: >= 5)
Gene RIFs: 346   (req: > 3)
Antibodies: 859   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 67
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (92)
IL12A
Tclin
Novelty:  0.05943184
Score:  0.996
Data Source:  Reactome,STRINGDB
IL23A
Tclin
Novelty:  0.00440193
Score:  0.995
Data Source:  Reactome,STRINGDB
IL23R
Tchem
Novelty:  0.00434717
Score:  0.991
Data Source:  Reactome,STRINGDB
IL12RB1
Tbio
Novelty:  0.00398741
Score:  0.973
Data Source:  Reactome,STRINGDB
IL12RB2
Tbio
Novelty:  0.02023198
Score:  0.972
Data Source:  Reactome,STRINGDB
IL10
Tbio
Novelty:  0.00004352
Score:  0.966
Data Source:  STRINGDB
IL4
Tbio
Novelty:  0.00005852
Score:  0.946
Data Source:  STRINGDB
IL13
Tbio
Novelty:  0.00021435
Score:  0.945
Data Source:  STRINGDB
TYK2
Tclin
Family:  Kinase
Novelty:  0.00237955
Score:  0.932
Data Source:  Reactome,STRINGDB
RELA
Tchem
Family:  TF
Novelty:  0.0007137
Score:  0.929
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (107)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-10 signaling
Reactome
Interleukin-12 family signaling
Reactome
Interleukin-12 signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-10 signaling
Interleukin-12 family signaling
Interleukin-12 signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (76)
Find Similar Targets
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
AgBase
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
8
8
0
1.3
97.8
2
4
0
1.2
92.9
1
3
0
1.4
91.9
4
3
1
1.2
83.1
2
2
0
1.2
78
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
97.8
0
1.2
92.9
0
1.4
91.9
1
1.2
83.1
0
1.2
78
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interleukin 12B
VGNC:4041
471723
Macaque
interleukin 12B
694747
Mouse
MGI:96540
16160
Rat
RGD:628704
64546
Dog
interleukin 12B
VGNC:41933
403976
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interleukin 12B
Macaque
interleukin 12B
Mouse
Rat
Dog
interleukin 12B
Publication Statistics
PubMed Score 60.91
PubMed score by year
PubTator Score 279.93
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title