You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
IL12A
Interleukin-12 subunit alpha

Protein Summary
Description
Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305579
  • ENSP00000303231
  • ENSG00000168811

Symbol
  • NKSF1
  • P35
  • CLMF
  • NFSK
  • NKSF1
  • IL-12A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
chemical
0.97
biological term
0.95
phenotype
0.83
virus perturbation
0.83


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.59   (req: < 5)
Gene RIFs: 228   (req: <= 3)
Antibodies: 834   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.59   (req: >= 5)
Gene RIFs: 228   (req: > 3)
Antibodies: 834   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 40
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (96)
SPDL1
Tbio
Novelty:  0.01399644
p_int:  0.991637769
p_ni:  0.008362231
Score:  0.187
Data Source:  BioPlex,STRINGDB
F11R
Tbio
Novelty:  0.00182817
p_int:  0.981391895
p_ni:  1.61e-7
p_wrong:  0.018607944
Score:  0.416
Data Source:  BioPlex,STRINGDB
FSTL1
Tbio
Novelty:  0.00557848
p_int:  0.954127365
p_ni:  0.045871395
p_wrong:  0.00000124
Score:  0.163
Data Source:  BioPlex,STRINGDB
COL14A1
Tbio
Novelty:  0.01760399
p_int:  0.95009592
p_ni:  0.04990408
Score:  0.165
Data Source:  BioPlex,STRINGDB
RAB3B
Tbio
Family:  Enzyme
Novelty:  0.02731183
p_int:  0.790561688
p_ni:  0.209289968
p_wrong:  0.000148343
Score:  0.21
Data Source:  BioPlex,STRINGDB
IL12B
Tclin
Novelty:  0.0157417
Score:  0.996
Data Source:  Reactome,STRINGDB
EBI3
Tbio
Novelty:  0.09651194
Score:  0.975
Data Source:  Reactome,STRINGDB
IL10
Tbio
Novelty:  0.00004352
Score:  0.968
Data Source:  STRINGDB
IL12RB2
Tbio
Novelty:  0.02023198
Score:  0.951
Data Source:  Reactome,STRINGDB
STAT1
Tchem
Family:  TF
Novelty:  0.0003383
Score:  0.951
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (52)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-10 signaling
Reactome
Interleukin-12 family signaling
Reactome
Interleukin-12 signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-10 signaling
Interleukin-12 family signaling
Interleukin-12 signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (46)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
AgBase
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Oral ulcer
1
6
0
1.1
99.5
5
4
1
1.4
93.4
primary biliary cirrhosis
3
3
0
1.4
90.4
2
2
0
1.1
89.6
3
2
0
1.4
78.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Oral ulcer
0
1.1
99.5
1
1.4
93.4
primary biliary cirrhosis
0
1.4
90.4
0
1.1
89.6
0
1.4
78.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interleukin 12A
VGNC:1843
460816
Macaque
interleukin 12A
703205
Mouse
MGI:96539
16159
Rat
RGD:620562
84405
Dog
interleukin 12A
VGNC:41932
403977
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interleukin 12A
Macaque
interleukin 12A
Mouse
Rat
Dog
interleukin 12A
Publication Statistics
PubMed Score 13.59
PubMed score by year
PubTator Score 349.30
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title