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Tclin
IL11RA
Interleukin-11 receptor subunit alpha

Protein Summary
Description
Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number. Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Multiple alternatively spliced transcript variants have been found for this gen ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318041
  • ENSP00000326500
  • ENSG00000137070
  • ENST00000441545
  • ENSP00000394391
  • ENST00000555003
  • ENSP00000450565
  • ENST00000602473
  • ENSP00000473647

Symbol
  • CRSDA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.98
transcription factor
0.84
disease perturbation
0.74
transcription factor perturbation
0.74
protein domain
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.13   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 294   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.13   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 294   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (79)
IL11
Tbio
Novelty:  0.00103994
Score:  0.983
Data Source:  Reactome,STRINGDB
IL6ST
Tclin
Novelty:  0.01026472
Score:  0.945
Data Source:  Reactome,STRINGDB
JAK1
Tclin
Family:  Kinase
Novelty:  0.00093625
Score:  0.917
Data Source:  Reactome,STRINGDB
TYK2
Tclin
Family:  Kinase
Novelty:  0.00237955
Score:  0.912
Data Source:  STRINGDB
JAK2
Tclin
Family:  Kinase
Novelty:  0.00022894
Score:  0.902
Data Source:  Reactome,STRINGDB
GALT
Tbio
Family:  Enzyme
Novelty:  0.0120291
Score:  0.801
Data Source:  STRINGDB
IL13
Tbio
Novelty:  0.00021435
Score:  0.756
Data Source:  STRINGDB
IL6
Tclin
Novelty:  0.00001819
Score:  0.728
Data Source:  STRINGDB
NUDT2
Tbio
Family:  Enzyme
Novelty:  0.0201004
Score:  0.72
Data Source:  STRINGDB
CNTF
Tbio
Novelty:  0.00091188
Score:  0.7
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (104)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
IL-6-type cytokine receptor ligand interactions
Reactome
Immune System
Reactome
Interleukin-6 family signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
IL-6-type cytokine receptor ligand interactions
Immune System
Interleukin-6 family signaling
Signaling by Interleukins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chemokine (C-C motif) ligand 27 measurement
1
1
1
80.5
7
3
2
1.1
77
adolescent idiopathic scoliosis
2
1
0
1.1
42.3
testosterone measurement
1
1
1
29
self reported educational attainment
1
1
1
7.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chemokine (C-C motif) ligand 27 measurement
1
80.5
2
1.1
77
adolescent idiopathic scoliosis
0
1.1
42.3
testosterone measurement
1
29
self reported educational attainment
1
7.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interleukin 11 receptor subunit alpha
VGNC:8901
100616505
Mouse
MGI:109123
16158
Rat
RGD:621332
245983
Dog
interleukin 11 receptor subunit alpha
VGNC:41931
481588
Horse
interleukin 11 receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:5967]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interleukin 11 receptor subunit alpha
Mouse
Rat
Dog
interleukin 11 receptor subunit alpha
Horse
interleukin 11 receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:5967]
Publication Statistics
PubMed Score 19.13
PubMed score by year
PubTator Score 47.82
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title