You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
IL10RB
Interleukin-10 receptor subunit beta

Protein Summary
Description
Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000290200
  • ENSP00000290200
  • ENSG00000243646

Symbol
  • CRFB4
  • D21S58
  • D21S66
  • CRFB4
  • CRF2-4
  • D21S58
  • D21S66
  • CDW210B
  • IL-10R2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
transcription factor perturbation
0.91
PubMedID
0.88
histone modification site profile
0.81
gene perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.41   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 316   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.41   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 316   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (109)
CTLA4
Tclin
Novelty:  0.00012781
p_int:  0.967759576
p_ni:  1.1e-7
p_wrong:  0.032240313
Score:  0.265
Data Source:  BioPlex,STRINGDB
IFNLR1
Tbio
Novelty:  0.01990628
Score:  0.996
Data Source:  Reactome,STRINGDB
IFNL3
Tbio
Novelty:  0.00069262
Score:  0.995
Data Source:  Reactome,STRINGDB
IL10RA
Tbio
Novelty:  0.00506068
Score:  0.995
Data Source:  Reactome,STRINGDB
IL22RA1
Tbio
Novelty:  0.01107638
Score:  0.989
Data Source:  Reactome,STRINGDB
TYK2
Tclin
Family:  Kinase
Novelty:  0.00237955
Score:  0.981
Data Source:  Reactome,STRINGDB
IFNL2
Tbio
Novelty:  0.01468568
Score:  0.981
Data Source:  Reactome,STRINGDB
IL10
Tbio
Novelty:  0.00004352
Score:  0.981
Data Source:  Reactome,STRINGDB
STAT3
Tchem
Family:  TF
Novelty:  0.00011808
Score:  0.979
Data Source:  Reactome,STRINGDB
IL22
Tbio
Novelty:  0.0023754
Score:  0.977
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets (9)
Explore Nearest Tclin Targets
Pathways (20)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-10 signaling
Reactome
Interleukin-20 family signaling
Reactome
Other interleukin signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-10 signaling
Interleukin-20 family signaling
Other interleukin signaling
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
0
1.1
67.8
interleukin-10 receptor B measurement
1
1
1
64
COVID-19
1
1
0
1.2
52.7
eosinophil count
1
1
1
42.3
eosinophil percentage of leukocytes
1
1
1
38.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
67.8
interleukin-10 receptor B measurement
1
64
COVID-19
0
1.2
52.7
eosinophil count
1
42.3
eosinophil percentage of leukocytes
1
38.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interleukin-10 receptor subunit beta
473966
Mouse
MGI:109380
16155
Rat
RGD:1560373
304091
Dog
interleukin 10 receptor subunit beta
100856489
Horse
interleukin 10 receptor subunit beta
100052549
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interleukin-10 receptor subunit beta
Mouse
Rat
Dog
interleukin 10 receptor subunit beta
Horse
interleukin 10 receptor subunit beta
Publication Statistics
PubMed Score 90.41
PubMed score by year
PubTator Score 69.63
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title