Protein Summary
Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells. The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.[provided by RefSeq, May 2011]
- ENST00000423557
- ENSP00000412237
- ENSG00000136634
- CSIF
- TGIF
- GVHDS
- IL-10
- IL10A
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
biological term | 1 | ||
chemical | 1 | ||
disease | 0.97 | ||
PubMedID | 0.9 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 27137.76 (req: < 5)
Gene RIFs: 2133 (req: <= 3)
Antibodies: 1504 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 27137.76 (req: >= 5)
Gene RIFs: 2133 (req: > 3)
Antibodies: 1504 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 72
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (786)
MTMR3
Family: Enzyme
Novelty: 0.04961778
p_int: 0.999900584
p_ni: 0.000072577
p_wrong: 0.000026839
Data Source: BioPlex
MTMR4
Family: Enzyme
Novelty: 0.09166984
p_int: 0.995871046
p_ni: 0.002614978
p_wrong: 0.001513975
Data Source: BioPlex
CCNA2
Novelty: 0.00049887
p_int: 0.995323546
p_ni: 0.004676454
Score: 0.188
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (19)
Upstream (2)
Downstream (17)
1 – 2 of 2
Pathways (174)
Reactome (8)
KEGG (22)
PathwayCommons (11)
WikiPathways (133)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation | ||||
Reactome | Immune System | ||||
Reactome | Interleukin-10 signaling | ||||
Reactome | Interleukin-12 family signaling | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cytokine Signaling in Immune system | ||||
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation | ||||
Immune System | ||||
Interleukin-10 signaling | ||||
Interleukin-12 family signaling | ||||
Viral Interactions (0)
Gene Ontology Terms (74)
Functions (3)
Components (2)
Processes (69)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Non-traceable Author Statement (NAS) | BHF-UCL | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (15)
Items per page:
1 – 5 of 15
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
Oral ulcer | 1 | 5 | 0 | 1.1 | 96.1 | ||||
6 | 2 | 1 | 1.3 | 96.1 | |||||
2 | 2 | 0 | 1.4 | 94.4 | |||||
4 | 3 | 0 | 1.2 | 88.8 | |||||
MAP kinase-activated protein kinase 2 measurement | 1 | 1 | 1 | 60.4 | |||||
Items per page:
1 – 5 of 15
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
Oral ulcer | 0 | 1.1 | 96.1 | ||||
1 | 1.3 | 96.1 | |||||
0 | 1.4 | 94.4 | |||||
0 | 1.2 | 88.8 | |||||
MAP kinase-activated protein kinase 2 measurement | 1 | 60.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | interleukin 10 | VGNC:52981 | 469657 | |||||
Macaque | interleukin 10 | 694931 | ||||||
Mouse | MGI:96537 | 16153 | ||||||
Rat | RGD:2886 | 25325 | ||||||
Dog | interleukin 10 | VGNC:41928 | 403628 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | interleukin 10 | |||||
Macaque | interleukin 10 | |||||
Mouse | ||||||
Rat | ||||||
Dog | interleukin 10 | |||||
Publication Statistics
PubMed Score 27137.76
PubMed score by year
PubTator Score 9741.91
PubTator score by year
Related Publications
Text Mined References (2855)
GeneRif Annotations (2133)
Items per page:
0 of 0
PMID | Year | Title |
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