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Tbio
IKZF5
Zinc finger protein Pegasus

Protein Summary
Description
DNA-binding protein that binds to the 5'GNNTGTNG-3' core sequence. Transcriptional repressor. Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Pegasus, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM, Jul 2002]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368886
  • ENSP00000357881
  • ENSG00000095574
  • ENST00000617859
  • ENSP00000478056

Symbol
  • ZNFN1A5
  • PEGASUS
  • ZNFN1A5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.86
virus perturbation
0.59
small molecule perturbation
0.58
transcription factor binding site profile
0.54
transcription factor perturbation
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.39   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 54   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.39   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 54   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (72)
CHD8
Tbio
Family:  Epigenetic
Novelty:  0.01177693
p_int:  0.999999991
p_ni:  9e-9
Score:  0.198
Data Source:  BioPlex,STRINGDB
MIB2
Tbio
Family:  Enzyme
Novelty:  0.044378
p_int:  0.99999983
p_ni:  1.7e-7
Score:  0.388
Data Source:  BioPlex,STRINGDB
ZC3H3
Tbio
Novelty:  0.26894046
p_int:  0.999999755
p_ni:  2.41e-7
p_wrong:  4e-9
Data Source:  BioPlex
IKZF2
Tbio
Family:  TF
Novelty:  0.01943733
p_int:  0.99999968
p_ni:  7.2e-8
p_wrong:  2.48e-7
Score:  0.657
Data Source:  BioPlex,STRINGDB
IKZF3
Tbio
Family:  TF
Novelty:  0.01038728
p_int:  0.999999557
p_ni:  4.43e-7
Score:  0.631
Data Source:  BioPlex,STRINGDB
AHDC1
Tdark
Novelty:  0.06647774
p_int:  0.999999547
p_ni:  4.53e-7
Data Source:  BioPlex
CCDC77
Tdark
Novelty:  2.54727442
p_int:  0.999998949
p_ni:  0.000001043
p_wrong:  8e-9
Data Source:  BioPlex
TCF7L2
Tbio
Family:  TF
Novelty:  0.00178694
p_int:  0.999996732
p_wrong:  0.000003267
Score:  0.265
Data Source:  BioPlex,STRINGDB
ZNF518B
Tdark
Novelty:  0.3785852
p_int:  0.999996266
p_ni:  4.2e-8
p_wrong:  0.000003692
Score:  0.232
Data Source:  BioPlex,STRINGDB
ZZZ3
Tdark
Family:  TF
Novelty:  0.23862921
p_int:  0.99999572
p_ni:  0.00000428
Score:  0.23
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
4
4
96.5
low density lipoprotein cholesterol measurement
5
4
5
91.8
apolipoprotein B measurement
1
1
1
56.8
mean reticulocyte volume
1
1
1
56
reticulocyte measurement
1
1
1
48.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
96.5
low density lipoprotein cholesterol measurement
5
91.8
apolipoprotein B measurement
1
56.8
mean reticulocyte volume
1
56
reticulocyte measurement
1
48.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
IKAROS family zinc finger 5
VGNC:7278
745440
Macaque
IKAROS family zinc finger 5
716950
Mouse
MGI:1914393
67143
Rat
RGD:1310965
309031
Dog
IKAROS family zinc finger 5
VGNC:41927
611212
Species
Name
OMA
EggNOG
Inparanoid
Chimp
IKAROS family zinc finger 5
Macaque
IKAROS family zinc finger 5
Mouse
Rat
Dog
IKAROS family zinc finger 5
Publication Statistics
PubMed Score 2.39
PubMed score by year
PubTator Score 34.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title