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Tbio
IKZF3
Zinc finger protein Aiolos

Protein Summary
Description
Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner. This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different iso ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000293068
  • ENSP00000462791
  • ENSG00000161405
  • ENST00000346243
  • ENSP00000341977
  • ENST00000346872
  • ENSP00000344544
  • ENST00000350532
  • ENSP00000344471
  • ENST00000351680
  • ENSP00000345622
  • ENST00000377944
  • ENSP00000367179
  • ENST00000377945
  • ENSP00000367180
  • ENST00000377952
  • ENSP00000367188
  • ENST00000377958
  • ENSP00000367194
  • ENST00000394189
  • ENSP00000377741
  • ENST00000439016
  • ENSP00000403027
  • ENST00000439167
  • ENSP00000403776
  • ENST00000467757
  • ENSP00000420463
  • ENST00000535189
  • ENSP00000438972
  • ENST00000583368
  • ENSP00000462452
  • ENST00000623724
  • ENSP00000485515

Symbol
  • ZNFN1A3
  • AIO
  • AIOLOS
  • ZNFN1A3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.81
transcription factor
0.71
phenotype
0.7
transcription factor binding site profile
0.64
biological process
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.46   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 429   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.46   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 429   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (101)
IKZF1
Tbio
Family:  TF
Novelty:  0.0016117
p_int:  0.999999936
p_ni:  1.4e-8
p_wrong:  5e-8
Score:  0.812
Data Source:  BioPlex,STRINGDB
IKZF4
Tbio
Family:  TF
Novelty:  0.10806913
p_int:  0.999999883
p_ni:  8e-9
p_wrong:  1.1e-7
Score:  0.906
Data Source:  BioPlex,STRINGDB
IKZF5
Tbio
Family:  TF
Novelty:  0.36596327
p_int:  0.999999557
p_ni:  4.43e-7
Score:  0.631
Data Source:  BioPlex,STRINGDB
SETMAR
Tbio
Family:  Epigenetic
Novelty:  0.02859547
p_int:  0.999934726
p_ni:  0.000048971
p_wrong:  0.000016303
Score:  0.588
Data Source:  BioPlex,STRINGDB
ESS2
Tbio
Novelty:  0.00163665
p_int:  0.957209772
p_ni:  0.04277727
p_wrong:  0.000012958
Score:  0.198
Data Source:  BioPlex,STRINGDB
GATAD2B
Tbio
Family:  TF
Novelty:  0.056775
p_int:  0.852573011
p_ni:  0.147426989
Score:  0.47
Data Source:  BioPlex,STRINGDB
IL2
Tchem
Novelty:  0.00003129
Score:  0.966
Data Source:  STRINGDB
HRAS
Tchem
Family:  Enzyme
Novelty:  0.00008069
Score:  0.943
Data Source:  STRINGDB
IL2RB
Tclin
Novelty:  0.0050905
Score:  0.939
Data Source:  STRINGDB
CRBN
Tclin
Novelty:  0.00385433
Score:  0.933
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (24)
Find Similar Targets
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (55)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
childhood onset asthma
5
6
0
1.3
99.3
17
16
1
1.2
99.1
high density lipoprotein cholesterol measurement
6
7
8
98
age at onset
3
5
2
1.2
97.8
lymphocyte count
5
5
5
97.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
childhood onset asthma
0
1.3
99.3
1
1.2
99.1
high density lipoprotein cholesterol measurement
8
98
age at onset
2
1.2
97.8
lymphocyte count
5
97.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
IKAROS family zinc finger 3
VGNC:12313
468232
Macaque
IKAROS family zinc finger 3
698083
Mouse
MGI:1342542
22780
Rat
RGD:1307024
303511
Dog
IKAROS family zinc finger 3
VGNC:41925
491020
Species
Name
OMA
EggNOG
Inparanoid
Chimp
IKAROS family zinc finger 3
Macaque
IKAROS family zinc finger 3
Mouse
Rat
Dog
IKAROS family zinc finger 3
Publication Statistics
PubMed Score 97.46
PubMed score by year
PubTator Score 66.72
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title