IKZF2
Zinc finger protein Helios
Protein Summary
Associates with Ikaros at centromeric heterochromatin. This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This protein forms homo- or hetero-dimers with other Ikaros family members, and is thought to function predominantly in early hematopoietic development. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
- ENST00000374319
- ENSP00000363439
- ENSG00000030419
- ENST00000374326
- ENSP00000363446
- ENST00000412444
- ENSP00000413680
- ENST00000431520
- ENSP00000396253
- ENST00000434687
- ENSP00000412869
- ENST00000439848
- ENSP00000389548
- ENST00000453575
- ENSP00000411444
- HELIOS
- ZNFN1A2
- ANF1A2
- HELIOS
- ZNF1A2
- ZNFN1A2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
trait | 0.99 | ||
virus perturbation | 0.88 | ||
gene perturbation | 0.71 | ||
tissue sample | 0.68 | ||
transcription factor | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 60.95 (req: < 5)
Gene RIFs: 51 (req: <= 3)
Antibodies: 327 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 60.95 (req: >= 5)
Gene RIFs: 51 (req: > 3)
Antibodies: 327 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0