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Tbio
IKBKG
NF-kappa-B essential modulator

Protein Summary
Description
Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'-linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination. This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immuni ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000594239
  • ENSP00000471166
  • ENSG00000269335
  • ENST00000611071
  • ENSP00000479662
  • ENST00000611176
  • ENSP00000478616
  • ENST00000618670
  • ENSP00000483825

Symbol
  • FIP3
  • NEMO
  • IP
  • IP1
  • IP2
  • FIP3
  • IKKG
  • IPD2
  • NEMO
  • FIP-3
  • Fip3p
  • IMD33
  • AMCBX1
  • EDAID1
  • IKKAP1
  • ZC2HC9
  • IKK-gamma
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
kinase perturbation
1
disease perturbation
0.99
pathway
0.98


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2429.51   (req: < 5)
Gene RIFs: 181   (req: <= 3)
Antibodies: 1102   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2429.51   (req: >= 5)
Gene RIFs: 181   (req: > 3)
Antibodies: 1102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 37
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (306)
IKBKB
Tchem
Family:  Kinase
Novelty:  0.00090202
p_int:  0.999999996
p_ni:  2e-9
p_wrong:  2e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
SDCCAG8
Tbio
Novelty:  0.0431837
p_int:  0.999999983
p_ni:  8e-9
p_wrong:  9e-9
Score:  0.189
Data Source:  BioPlex,STRINGDB
CHUK
Tchem
Family:  Kinase
Novelty:  0.00151532
p_int:  0.999999943
p_ni:  2.8e-8
p_wrong:  2.9e-8
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
MAP3K14
Tchem
Family:  Kinase
Novelty:  0.0350173
p_int:  0.999994493
p_ni:  0.000005485
p_wrong:  2.2e-8
Score:  0.99
Data Source:  BioPlex,STRINGDB
CENPF
Tbio
Novelty:  0.00676983
p_int:  0.999987051
p_ni:  0.000012949
Data Source:  BioPlex
SYNC
Tbio
Novelty:  0.04605223
p_int:  0.999923656
p_ni:  0.000076334
p_wrong:  1e-8
Data Source:  BioPlex
SEMA4C
Tbio
Novelty:  0.01237067
p_int:  0.999606906
p_ni:  0.000393055
p_wrong:  3.9e-8
Data Source:  BioPlex
LTBR
Tbio
Novelty:  0.003823
p_int:  0.998466916
p_ni:  0.001533073
p_wrong:  1.2e-8
Score:  0.42
Data Source:  BioPlex,STRINGDB
INSYN2
Tdark
Novelty:  2.55244594
p_int:  0.998030021
p_ni:  0.001969957
p_wrong:  2.3e-8
Data Source:  BioPlex
PTS
Tbio
Family:  Enzyme
Novelty:  0.00279396
p_int:  0.995056081
p_ni:  0.00466857
p_wrong:  0.000275349
Data Source:  BioPlex
Nearest Tclin Targets (6)
Explore Nearest Tclin Targets
Pathways (190)
Activation of NF-kappaB in B cells (R-HSA-1169091)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 72
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NF-kappaB in B cells
Reactome
Adaptive Immune System
Reactome
Antigen processing-Cross presentation
Reactome
C-type lectin receptors (CLRs)
Reactome
CLEC7A (Dectin-1) signaling
Name
Explore in Pharos
Explore in Source
Activation of NF-kappaB in B cells
Adaptive Immune System
Antigen processing-Cross presentation
C-type lectin receptors (CLRs)
CLEC7A (Dectin-1) signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (46)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
4
2
4
96.6
red blood cell distribution width
1
1
1
89.7
hemolysis
1
1
0
3.8
80.1
erythrocyte count
1
1
1
79.4
hematocrit
1
1
1
77.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
4
96.6
red blood cell distribution width
1
89.7
hemolysis
0
3.8
80.1
erythrocyte count
1
79.4
hematocrit
1
77.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
inhibitor of nuclear factor kappa B kinase subunit gamma
701237
Mouse
MGI:1338074
16151
Rat
RGD:735223
309295
Dog
inhibitor of nuclear factor kappa B kinase subunit gamma
VGNC:41922
612576
Horse
inhibitor of nuclear factor kappa B kinase subunit gamma
VGNC:18986
100058432
Species
Name
OMA
EggNOG
Inparanoid
Macaque
inhibitor of nuclear factor kappa B kinase subunit gamma
Mouse
Rat
Dog
inhibitor of nuclear factor kappa B kinase subunit gamma
Horse
inhibitor of nuclear factor kappa B kinase subunit gamma
Publication Statistics
PubMed Score 2429.51
PubMed score by year
PubTator Score 934.50
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title