Tchem IKBKB Inhibitor of nuclear factor kappa-B kinase subunit beta

Protein Summary

Description

Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation. The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Sep 2011]

Uniprot Accession IDs

• O14920
• B4DZ30
• B4E0U4
• O75327
• I-kappa-B-kinase beta

Gene Name

• IKBKB

Ensembl ID

• ENST00000416505
• ENSP00000404920
• ENSG00000104365
• ENST00000520810
• ENSP00000430684
• ENST00000520835
• ENSP00000430868
• ENST00000649612
• ENSP00000497383

Symbol

• IKKB
• IKK2
• IKKB
• IMD15
• IMD15A
• IMD15B
• NFKBIKB
• IKK-beta

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	1
biological term	0.99
chemical	0.99
kinase	0.99
molecular function	0.99

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Serine/threonine Protein Kinase / Inhibitor Of Nuclear Factor Kappa-b Kinase Subunit Beta

DTO Classes

Protein / Kinase / Protein Kinase / Other Group / Ikk Family / Inhibitor Of Nuclear Factor Kappa-b Kinase Subunit Beta

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1159.2   (req: < 5)

Gene RIFs: 229   (req: <= 3)

Antibodies: 2128   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1159.2   (req: >= 5)

Gene RIFs: 229   (req: > 3)

Antibodies: 2128   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 38

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 221

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0