You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
IKBIP
Inhibitor of nuclear factor kappa-B kinase-interacting protein

Protein Summary
Description
Target of p53/TP53 with pro-apoptotic function.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299157
  • ENSP00000299157
  • ENSG00000166130
  • ENST00000342502
  • ENSP00000343471
  • ENST00000393042
  • ENSP00000376762

Symbol
  • IKIP
  • IKIP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.86
phenotype
0.86
transcription factor perturbation
0.8
histone modification site profile
0.79
kinase perturbation
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.43   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 181   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.43   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 181   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (77)
TNIP1
Tbio
Novelty:  0.0147254
p_int:  0.999997241
p_ni:  0.000002759
Score:  0.194
Data Source:  BioPlex,STRINGDB
BORCS7
Tbio
Novelty:  0.14135922
p_int:  0.999997002
p_ni:  0.000002971
p_wrong:  2.8e-8
Data Source:  BioPlex
WASHC3
Tdark
Novelty:  0.18307321
p_int:  0.999994296
p_ni:  0.000005704
Data Source:  BioPlex
PCNT
Tbio
Novelty:  0.00369505
p_int:  0.999992105
p_ni:  0.000007895
Data Source:  BioPlex
VPS52
Tbio
Novelty:  0.01439614
p_int:  0.999991699
p_ni:  0.000008301
Data Source:  BioPlex
MSR1
Tbio
Novelty:  0.0037302
p_int:  0.999991206
p_ni:  0.000008794
Score:  0.165
Data Source:  BioPlex,STRINGDB
EXOC1
Tbio
Novelty:  0.01073858
p_int:  0.99998364
p_ni:  0.00001636
Data Source:  BioPlex
ABI1
Tbio
Novelty:  0.00796638
p_int:  0.999979814
p_ni:  0.000020186
Data Source:  BioPlex
NCKAP1
Tbio
Novelty:  0.03486454
p_int:  0.999976427
p_ni:  0.000023573
Data Source:  BioPlex
AGGF1
Tbio
Novelty:  0.02757407
p_int:  0.999976104
p_ni:  0.000023896
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
1
2
2
45.1
hip circumference
1
1
1
31.4
body fat percentage
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
2
45.1
hip circumference
1
31.4
body fat percentage
1
17.8
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1914704
67454
Rat
RGD:1305457
314730
Dog
IKBKB interacting protein
VGNC:54211
482619
Horse
IKBKB interacting protein
VGNC:51983
100052491
Cow
IKBKB interacting protein
540640
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
IKBKB interacting protein
Horse
IKBKB interacting protein
Cow
IKBKB interacting protein
Publication Statistics
PubMed Score 6.43
PubMed score by year
PubTator Score 0.50
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title