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Tbio
IHH
Indian hedgehog protein

Protein Summary
Description
Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP) (By similarity). This gene encodes a member of the hedgehog family of proteins. The encoded preproprotein is proteolytically processed to generate multiple protein products, including an N-terminal fragment that is involved in signaling. Hedgehog family proteins are essential secreted signaling molecules that regulate a variety of developmental processes including growth, patterning and morphogenesis. The protein encoded by this gene specifically plays a role in bone growth and differentiation. Mutations in this gene are the cause of brachydactyly type A1, which is characteriz ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295731
  • ENSP00000295731
  • ENSG00000163501

Symbol
  • BDA1
  • HHG2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
protein domain
0.97
disease
0.77
phenotype
0.72
biological term
0.69


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 587.37   (req: < 5)
Gene RIFs: 72   (req: <= 3)
Antibodies: 477   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 587.37   (req: >= 5)
Gene RIFs: 72   (req: > 3)
Antibodies: 477   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 51
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (224)
PTCH1
Tbio
Novelty:  0.00077635
Score:  0.997
Data Source:  STRINGDB
PTCH2
Tbio
Novelty:  0.00927849
Score:  0.99
Data Source:  STRINGDB
SMO
Tclin
Family:  GPCR
Novelty:  0.03235855
Score:  0.981
Data Source:  STRINGDB
HHIP
Tbio
Novelty:  0.00982404
Score:  0.98
Data Source:  STRINGDB
HHAT
Tchem
Family:  Enzyme
Novelty:  0.003077
Score:  0.969
Data Source:  STRINGDB
BOC
Tbio
Novelty:  0.10938194
Score:  0.963
Data Source:  STRINGDB
CDON
Tbio
Novelty:  0.00447262
Score:  0.962
Data Source:  STRINGDB
DISP2
Tbio
Novelty:  0.09502772
Score:  0.957
Data Source:  STRINGDB
GAS1
Tbio
Novelty:  0.00423304
Score:  0.95
Data Source:  STRINGDB
PTHLH
Tbio
Novelty:  0.00050137
Score:  0.938
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (96)
Activation of SMO (R-HSA-5635838)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of SMO
Reactome
Class B/2 (Secretin family receptors)
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Activation of SMO
Class B/2 (Secretin family receptors)
Disease
Diseases of signal transduction
GPCR ligand binding
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
5
8
9
97.7
BMI-adjusted waist circumference
1
3
3
60.2
sex hormone-binding globulin measurement
2
1
2
40.7
neutrophil percentage of leukocytes
1
1
1
27.3
BMI-adjusted hip circumference
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
9
97.7
BMI-adjusted waist circumference
3
60.2
sex hormone-binding globulin measurement
2
40.7
neutrophil percentage of leukocytes
1
27.3
BMI-adjusted hip circumference
1
24.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
indian hedgehog
VGNC:10848
470652
Macaque
indian hedgehog
704046
Mouse
MGI:96533
16147
Rat
RGD:620021
84399
Horse
indian hedgehog [Source:HGNC Symbol;Acc:HGNC:5956]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
indian hedgehog
Macaque
indian hedgehog
Mouse
Rat
Horse
indian hedgehog [Source:HGNC Symbol;Acc:HGNC:5956]
Publication Statistics
PubMed Score 587.37
PubMed score by year
PubTator Score 46.92
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title