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Tbio
IGSF8
Immunoglobulin superfamily member 8

Protein Summary
Description
May play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. May regulate proliferation and differentiation of keratinocytes. May be a negative regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. May also play a role on integrin-dependent morphology and motility functions. May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain. This gene encodes a member the EWI subfamily of the immunoglobulin protein superfamily. Members of this family contain a single transmembrane domain, an EWI (Glu-Trp-Ile)-motif and a variable number of immunoglobulin domains. This protein interacts with the tetraspanins CD81 and CD9 and may regulate their role in certain cellular functions including cel ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314485
  • ENSP00000316664
  • ENSG00000162729
  • ENST00000368086
  • ENSP00000357065
  • ENST00000614243
  • ENSP00000477565

Symbol
  • CD81P3
  • EWI2
  • KCT4
  • EWI2
  • PGRL
  • CD316
  • EWI-2
  • KCT-4
  • CD81P3
  • LIR-D1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.71
transcription factor
0.63
transcription factor binding site profile
0.6
histone modification site profile
0.58
protein domain
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.28   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 223   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.28   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 223   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (70)
CLEC4A
Tbio
Novelty:  0.01821643
p_int:  0.999968472
p_ni:  0.000031528
Data Source:  BioPlex
DNAJC14
Tbio
Novelty:  0.05383843
p_int:  0.999961471
p_ni:  4.4e-8
p_wrong:  0.000038485
Score:  0.204
Data Source:  BioPlex,STRINGDB
DNAH14
Tbio
Novelty:  0.28289652
p_int:  0.999724323
p_ni:  0.000275677
Score:  0.204
Data Source:  BioPlex,STRINGDB
GDPD5
Tbio
Family:  Enzyme
Novelty:  0.05871733
p_int:  0.999401246
p_ni:  0.000598752
p_wrong:  2e-9
Score:  0.165
Data Source:  BioPlex,STRINGDB
TMX1
Tbio
Novelty:  0.03444237
p_int:  0.999043495
p_ni:  0.000956505
Data Source:  BioPlex
TBRG4
Tbio
Novelty:  0.03556613
p_int:  0.998467909
p_ni:  0.001532091
Data Source:  BioPlex
HBA1
Tclin
Novelty:  0.00094113
p_int:  0.994241471
p_ni:  0.00575843
p_wrong:  9.9e-8
Data Source:  BioPlex
CD9
Tbio
Novelty:  0.00095308
p_int:  0.993714698
p_ni:  4.6e-8
p_wrong:  0.006285257
Score:  0.898
Data Source:  BioPlex,STRINGDB
CLDN19
Tbio
Novelty:  0.02391772
p_int:  0.982771766
p_ni:  0.017228152
p_wrong:  8.2e-8
Data Source:  BioPlex
TMEM30B
Tbio
Novelty:  0.26735006
p_int:  0.978639558
p_ni:  0.02136044
p_wrong:  2e-9
Score:  0.153
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: pid
Beta1 integrin cell surface interactions
PathwayCommons: pid
Alpha4 beta1 integrin signaling events
Name
Explore in Pharos
Explore in Source
Beta1 integrin cell surface interactions
Alpha4 beta1 integrin signaling events
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
granulocyte count
1
2
2
83.1
electrocardiography
1
1
3
30.6
educational attainment
1
1
1
16.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
granulocyte count
2
83.1
electrocardiography
3
30.6
educational attainment
1
16.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
immunoglobulin superfamily member 8
VGNC:10667
469549
Macaque
immunoglobulin superfamily member 8
720186
Mouse
MGI:2154090
140559
Rat
RGD:1311500
304979
Dog
immunoglobulin superfamily member 8
VGNC:41918
100855523
Species
Name
OMA
EggNOG
Inparanoid
Chimp
immunoglobulin superfamily member 8
Macaque
immunoglobulin superfamily member 8
Mouse
Rat
Dog
immunoglobulin superfamily member 8
Publication Statistics
PubMed Score 38.28
PubMed score by year
PubTator Score 23.16
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title