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Tbio
IGSF5
Immunoglobulin superfamily member 5

Protein Summary
Description
Provides, together with MAGI1, an adhesion machinery at tight junctions, which may regulate the permeability of kidney glomerulus and small intestinal epithelial cells. Mediates calcium-independent homophilic cell adhesion. In testis, it may function as a cell adhesion molecule rather than a tight-junction protein. It may participate in the adhesion between spermatogonia-spermatogonia, spermatogonia-Sertoli cells, and Sertoli cells-Sertoli cells (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380588
  • ENSP00000369962
  • ENSG00000183067

Symbol
  • JAM4
  • GSF5
  • JAM4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.76
trait
0.75
protein domain
0.58
microRNA
0.51
cell type or tissue
0.49


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.8   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 104   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.8   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 104   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (31)
JAM2
Tbio
Novelty:  0.02059056
Score:  0.939
Data Source:  STRINGDB
F11R
Tbio
Novelty:  0.00182817
Score:  0.932
Data Source:  STRINGDB
JAM3
Tbio
Novelty:  0.01028735
Score:  0.931
Data Source:  STRINGDB
TJP1
Tbio
Novelty:  0.00040365
Score:  0.923
Data Source:  STRINGDB
MAGI1
Tbio
Family:  Enzyme
Novelty:  0.06837323
Score:  0.844
Data Source:  STRINGDB
LNX1
Tbio
Family:  Enzyme
Novelty:  0.01555905
Score:  0.759
Data Source:  STRINGDB
LNX2
Tbio
Novelty:  0.03889661
Score:  0.717
Data Source:  STRINGDB
OCLN
Tbio
Novelty:  0.00047671
Score:  0.716
Data Source:  STRINGDB
JAML
Tbio
Novelty:  0.05682584
Score:  0.682
Data Source:  STRINGDB
ESAM
Tbio
Novelty:  0.00462452
Score:  0.663
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
immunoglobulin superfamily member 5
VGNC:14664
458555
Macaque
immunoglobulin superfamily member 5
722561
Mouse
MGI:1919308
72058
Rat
RGD:1359642
304000
Dog
immunoglobulin superfamily member 5
VGNC:53028
610716
Species
Name
OMA
EggNOG
Inparanoid
Chimp
immunoglobulin superfamily member 5
Macaque
immunoglobulin superfamily member 5
Mouse
Rat
Dog
immunoglobulin superfamily member 5
Publication Statistics
PubMed Score 9.80
PubMed score by year
PubTator Score 3.37
PubTator score by year
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Related Publications
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PMID
Year
Title