Tbio IGSF3 Immunoglobulin superfamily member 3

Protein Summary

Description

The protein encoded by this gene is an immunoglobulin-like membrane protein containing several V-type Ig-like domains. A mutation in this gene has been associated with bilateral nasolacrimal duct obstruction (LCDD). [provided by RefSeq, Jun 2016]

Uniprot Accession IDs

• O75054
• A6NJZ6
• A6NMC7
• IgSF3

Gene Name

• IGSF3

Ensembl ID

• ENST00000318837
• ENSP00000321184
• ENSG00000143061
• ENST00000369483
• ENSP00000358495
• ENST00000369486
• ENSP00000358498

Symbol

• EWI3
• KIAA0466
• V8
• LCDD
• EWI-3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.74
microRNA	0.74
PubMedID	0.68
kinase perturbation	0.66
transcription factor	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.98   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 162   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.98   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 162   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0