You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
IGSF3
Immunoglobulin superfamily member 3

Protein Summary
Description
The protein encoded by this gene is an immunoglobulin-like membrane protein containing several V-type Ig-like domains. A mutation in this gene has been associated with bilateral nasolacrimal duct obstruction (LCDD). [provided by RefSeq, Jun 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318837
  • ENSP00000321184
  • ENSG00000143061
  • ENST00000369483
  • ENSP00000358495
  • ENST00000369486
  • ENSP00000358498

Symbol
  • EWI3
  • KIAA0466
  • V8
  • LCDD
  • EWI-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.74
microRNA
0.74
PubMedID
0.68
kinase perturbation
0.66
transcription factor
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.98   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 162   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.98   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 162   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (46)
NAALADL2
Tbio
Family:  Enzyme
Novelty:  0.17299124
p_int:  0.999999988
p_ni:  1.2e-8
Score:  0.345
Data Source:  BioPlex,STRINGDB
CACNG1
Tbio
Family:  IC
Novelty:  0.11899252
p_int:  0.999999445
p_ni:  5.56e-7
Data Source:  BioPlex
CDR2
Tbio
Novelty:  0.00141419
p_int:  0.999997391
p_ni:  0.000002609
Score:  0.619
Data Source:  BioPlex,STRINGDB
LGALS9
Tchem
Novelty:  0.00381766
p_int:  0.99993588
p_ni:  0.000064118
p_wrong:  2e-9
Score:  0.15
Data Source:  BioPlex,STRINGDB
SPPL2B
Tchem
Family:  Enzyme
Novelty:  0.0274774
p_int:  0.999914058
p_ni:  0.000085941
p_wrong:  1e-9
Data Source:  BioPlex
DEFA1
Tbio
Novelty:  0.01027492
p_int:  0.992452714
p_ni:  0.007477503
p_wrong:  0.000069784
Data Source:  BioPlex
AMIGO1
Tbio
Novelty:  0.00864791
p_int:  0.937795409
p_ni:  0.060565516
p_wrong:  0.001639075
Data Source:  BioPlex
DHFR2
Tbio
Family:  Enzyme
Novelty:  0.02374466
p_int:  0.881869317
p_ni:  0.116753615
p_wrong:  0.001377068
Data Source:  BioPlex
CROCC
Tbio
Novelty:  0.03718561
Score:  0.673
Data Source:  STRINGDB
RABGEF1
Tbio
Novelty:  0.02830695
Score:  0.66
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
multiple sclerosis
6
4
0
1.3
99.3
primary biliary cirrhosis
4
3
3
1.3
93.4
glomerular filtration rate
1
1
1
58.1
gait measurement
1
1
1
27.9
neutrophil count
1
1
1
22.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
multiple sclerosis
0
1.3
99.3
primary biliary cirrhosis
3
1.3
93.4
glomerular filtration rate
1
58.1
gait measurement
1
27.9
neutrophil count
1
22.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
immunoglobulin superfamily member 3
VGNC:6884
469428
Macaque
immunoglobulin superfamily member 3
713579
Mouse
MGI:1926158
78908
Rat
RGD:1307796
295325
Dog
immunoglobulin superfamily member 3
VGNC:41916
483139
Species
Name
OMA
EggNOG
Inparanoid
Chimp
immunoglobulin superfamily member 3
Macaque
immunoglobulin superfamily member 3
Mouse
Rat
Dog
immunoglobulin superfamily member 3
Publication Statistics
PubMed Score 23.98
PubMed score by year
PubTator Score 60.28
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title