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Tdark
IGKC
Immunoglobulin kappa constant

Protein Summary
Description
Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affin ...more
Uniprot Accession IDs
Gene Name
Symbol
  • Km
  • HCAK1
  • IGKCD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.8
PubMedID
0.8
pathway
0.74
drug
0.7
cell line
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (81)
DDX31
Tbio
Family:  Enzyme
Novelty:  2.84646195
p_int:  0.999989613
p_ni:  0.000010387
Data Source:  BioPlex
DDX19B
Tbio
Family:  Enzyme
Novelty:  0.0504568
p_int:  0.997419251
p_ni:  0.002580749
Data Source:  BioPlex
TBC1D22B
Tbio
Novelty:  0.49852962
p_int:  0.995397405
p_ni:  0.004602595
Data Source:  BioPlex
HBM
Tdark
Novelty:  0.02658671
p_int:  0.994217719
p_ni:  0.005782246
p_wrong:  3.4e-8
Data Source:  BioPlex
CDK15
Tchem
Family:  Kinase
Novelty:  0.3870338
p_int:  0.993512848
p_ni:  0.006487089
p_wrong:  6.4e-8
Data Source:  BioPlex
PDE4DIP
Tbio
Novelty:  0.03414104
p_int:  0.99322146
p_ni:  0.006778479
p_wrong:  6.1e-8
Data Source:  BioPlex
ASCC1
Tbio
Novelty:  0.1280098
p_int:  0.988787785
p_ni:  0.011212152
p_wrong:  6.3e-8
Data Source:  BioPlex
ZSCAN20
Tdark
Family:  TF
Novelty:  0.37441538
p_int:  0.988259538
p_ni:  0.011740334
p_wrong:  1.28e-7
Data Source:  BioPlex
ALDH2
Tclin
Family:  Enzyme
Novelty:  0.00077122
p_int:  0.98698223
p_ni:  0.013017768
p_wrong:  3e-9
Data Source:  BioPlex
ALDH3A1
Tchem
Family:  Enzyme
Novelty:  0.00592398
p_int:  0.984573936
p_ni:  0.015426064
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (27)
Adaptive Immune System (R-HSA-1280218)

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Items per page:
1 – 5 of 26
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Reactome
Binding and Uptake of Ligands by Scavenger Receptors
Reactome
CD22 mediated BCR regulation
Reactome
Cell surface interactions at the vascular wall
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Binding and Uptake of Ligands by Scavenger Receptors
CD22 mediated BCR regulation
Cell surface interactions at the vascular wall
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubTator Score 21.12
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title