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Tbio
IGHMBP2
DNA-binding protein SMUBP-2

Protein Summary
Description
5' to 3' helicase that unwinds RNA and DNA duplices in an ATP-dependent reaction. Acts as a transcription regulator. Required for the transcriptional activation of the flounder liver-type antifreeze protein gene. Exhibits strong binding specificity to the enhancer element B of the flounder antifreeze protein gene intron. Binds to the insulin II gene RIPE3B enhancer region. May be involved in translation (By similarity). DNA-binding protein specific to 5'-phosphorylated single-stranded guanine-rich sequence related to the immunoglobulin mu chain switch region. Preferentially binds to the 5'-GGGCT-3' motif. Interacts with tRNA-Tyr. Stimulates the transcription of the human neurotropic virus JCV. This gene encodes a helicase superfamily member that binds a specific DNA sequence from the immunoglobulin mu chain switch region. Mutations in this gene lead to spinal muscle atrophy with respiratory distress type 1. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000255078
  • ENSP00000255078
  • ENSG00000132740

Symbol
  • SMBP2
  • SMUBP2
  • HCSA
  • HMN6
  • CATF1
  • CMT2S
  • SMARD1
  • SMUBP2
  • ZFAND7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
molecular function
1
histone modification site profile
0.91
protein domain
0.85
co-expressed gene
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.66   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 76   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.66   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (93)
NELFE
Tbio
Novelty:  0.02136256
p_int:  0.999986156
p_ni:  0.000002681
p_wrong:  0.000011164
Score:  0.681
Data Source:  BioPlex,STRINGDB
TUBA8
Tbio
Novelty:  0.06454549
p_int:  0.999716362
p_ni:  0.000283552
p_wrong:  8.5e-8
Score:  0.202
Data Source:  BioPlex,STRINGDB
NELFA
Tbio
Novelty:  0.09727823
p_int:  0.995990791
p_ni:  0.000009187
p_wrong:  0.004000021
Score:  0.757
Data Source:  BioPlex,STRINGDB
WDR89
Tdark
Novelty:  1.32691886
p_int:  0.995189514
p_ni:  0.004810485
p_wrong:  1e-9
Score:  0.203
Data Source:  BioPlex,STRINGDB
NLE1
Tbio
Novelty:  0.03831535
p_int:  0.987602814
p_ni:  0.012397183
p_wrong:  3e-9
Score:  0.191
Data Source:  BioPlex,STRINGDB
THAP12
Tbio
Family:  TF
Novelty:  0.21092098
p_int:  0.894190709
p_ni:  0.105809291
Data Source:  BioPlex
WDR12
Tbio
Novelty:  0.03409059
p_int:  0.83052958
p_ni:  0.16947042
Score:  0.269
Data Source:  BioPlex,STRINGDB
GRSF1
Tbio
Novelty:  0.05905648
p_int:  0.806889174
p_ni:  0.193110826
Score:  0.634
Data Source:  BioPlex,STRINGDB
RPL5
Tbio
Novelty:  0.00663792
p_int:  0.797832832
p_ni:  0.202167168
Score:  0.165
Data Source:  BioPlex,STRINGDB
LAS1L
Tbio
Novelty:  0.15470637
Score:  0.819
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (24)
Find Similar Targets
Items per page:
10
1 – 10 of 13
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
4
4
5
86
triglyceride measurement
3
3
3
74.6
heel bone mineral density
2
1
3
72.6
apolipoprotein A 1 measurement
1
1
1
59
calcium measurement
1
1
1
13.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
5
86
triglyceride measurement
3
74.6
heel bone mineral density
3
72.6
apolipoprotein A 1 measurement
1
59
calcium measurement
1
13.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
immunoglobulin mu binding protein 2
VGNC:1063
451384
Mouse
MGI:99954
20589
Rat
RGD:68325
29532
Dog
immunoglobulin mu binding protein 2
VGNC:41910
483686
Horse
immunoglobulin mu binding protein 2
VGNC:18977
100060088
Species
Name
OMA
EggNOG
Inparanoid
Chimp
immunoglobulin mu binding protein 2
Mouse
Rat
Dog
immunoglobulin mu binding protein 2
Horse
immunoglobulin mu binding protein 2
Publication Statistics
PubMed Score 89.66
PubMed score by year
PubTator Score 79.41
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title