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Tclin
IGHG4
Immunoglobulin heavy constant gamma 4

Protein Summary
Description
Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affin ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000390543
  • ENSP00000374985
  • ENSG00000211892
  • ENST00000618981
  • ENSP00000483393
  • ENSG00000277016
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.49
pathway
0.47
interacting protein
0.43
tissue
0.38
disease
0.34


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (35)
ALDH2
Tclin
Family:  Enzyme
Novelty:  0.00077122
p_int:  0.999994149
p_ni:  0.00000583
p_wrong:  2.1e-8
Data Source:  BioPlex
RAD51AP1
Tbio
Novelty:  0.04859066
p_int:  0.998436853
p_ni:  0.000142657
p_wrong:  0.001420489
Data Source:  BioPlex
SNX27
Tbio
Novelty:  0.02419724
p_int:  0.997372442
p_ni:  0.000005619
p_wrong:  0.002621939
Data Source:  BioPlex
PIK3CA
Tclin
Family:  Kinase
Novelty:  0.00044273
Data Source:  Reactome
FCGR2A
Tbio
Novelty:  0.00078918
Data Source:  Reactome
ELMO2
Tbio
Novelty:  0.04258272
Data Source:  Reactome
C2
Tchem
Novelty:  0.00974862
Data Source:  Reactome
SERPING1
Tbio
Family:  Enzyme
Novelty:  0.00068448
Data Source:  Reactome
C1QC
Tbio
Novelty:  0.0286777
Data Source:  Reactome
PLCG2
Tchem
Family:  Enzyme
Novelty:  0.00294726
Data Source:  Reactome
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
Classical antibody-mediated complement activation (R-HSA-173623)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Classical antibody-mediated complement activation
Reactome
Complement cascade
Reactome
Creation of C4 and C2 activators
Reactome
Cytokine Signaling in Immune system
Reactome
FCGR activation
Name
Explore in Pharos
Explore in Source
Classical antibody-mediated complement activation
Complement cascade
Creation of C4 and C2 activators
Cytokine Signaling in Immune system
FCGR activation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum non-albumin protein measurement
1
2
2
84.8
serum non-albumin protein measurement
1
2
2
84.8
IgG index
1
1
1
81.9
IgG index
1
1
1
81.9
blood protein measurement
1
2
2
62.8
Items per page:
1 – 5 of 12
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum non-albumin protein measurement
2
84.8
serum non-albumin protein measurement
2
84.8
IgG index
1
81.9
IgG index
1
81.9
blood protein measurement
2
62.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubTator Score 5.57
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title