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Tclin
IGHG2
Immunoglobulin heavy constant gamma 2

Protein Summary
Description
Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affin ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000390545
  • ENSP00000374987
  • ENSG00000211893
  • ENST00000621803
  • ENSP00000480351
  • ENSG00000274497
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.87
drug
0.57
pathway
0.47
tissue sample
0.45
tissue
0.42


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (64)
DDX19B
Tbio
Family:  Enzyme
Novelty:  0.0504568
p_int:  0.999842884
p_ni:  0.000157113
p_wrong:  3e-9
Data Source:  BioPlex
PDE4DIP
Tbio
Novelty:  0.03414104
p_int:  0.999633206
p_ni:  0.000366776
p_wrong:  1.8e-8
Data Source:  BioPlex
CDK15
Tchem
Family:  Kinase
Novelty:  0.3870338
p_int:  0.998640949
p_ni:  0.001359023
p_wrong:  2.8e-8
Data Source:  BioPlex
ASCC1
Tbio
Novelty:  0.1280098
p_int:  0.998365438
p_ni:  0.001632569
p_wrong:  0.000001993
Data Source:  BioPlex
SNX27
Tbio
Novelty:  0.02419724
p_int:  0.9981844
p_ni:  0.001813648
p_wrong:  0.000001952
Data Source:  BioPlex
DDX31
Tbio
Family:  Enzyme
Novelty:  2.84646195
p_int:  0.997979622
p_ni:  0.002020375
p_wrong:  3e-9
Data Source:  BioPlex
GDPD1
Tbio
Family:  Enzyme
Novelty:  0.28722153
p_int:  0.993894338
p_ni:  0.00607276
p_wrong:  0.000032903
Data Source:  BioPlex
CYP3A5
Tclin
Family:  Enzyme
Novelty:  0.00105607
p_int:  0.99256231
p_ni:  0.007435176
p_wrong:  0.000002514
Data Source:  BioPlex
SUSD3
Tdark
Novelty:  0.43699506
p_int:  0.99250552
p_ni:  0.003230268
p_wrong:  0.004264212
Data Source:  BioPlex
ALDH3A1
Tchem
Family:  Enzyme
Novelty:  0.00592398
p_int:  0.988867972
p_ni:  0.011132026
p_wrong:  1e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Classical antibody-mediated complement activation (R-HSA-173623)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Classical antibody-mediated complement activation
Reactome
Complement cascade
Reactome
Creation of C4 and C2 activators
Reactome
FCGR activation
Reactome
Fcgamma receptor (FCGR) dependent phagocytosis
Name
Explore in Pharos
Explore in Source
Classical antibody-mediated complement activation
Complement cascade
Creation of C4 and C2 activators
FCGR activation
Fcgamma receptor (FCGR) dependent phagocytosis
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IgG index
1
1
1
81.9
IgG index
1
1
1
81.9
serum albumin measurement
1
2
2
67.6
serum albumin measurement
1
2
2
67.6
blood protein measurement
1
2
2
62.6
Items per page:
1 – 5 of 10
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IgG index
1
81.9
IgG index
1
81.9
serum albumin measurement
2
67.6
serum albumin measurement
2
67.6
blood protein measurement
2
62.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubTator Score 7.43
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title