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Tbio
IGHA2
Immunoglobulin heavy constant alpha 2

Protein Summary
Description
Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affin ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000390539
  • ENSP00000374981
  • ENSG00000211890
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.6
tissue
0.56
cellular component
0.43
disease
0.37
drug
0.35


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (33)
DDX31
Tbio
Family:  Enzyme
Novelty:  2.84646195
p_int:  0.999998429
p_ni:  0.000001503
p_wrong:  6.8e-8
Data Source:  BioPlex
FRMD1
Tdark
Novelty:  0.96833141
p_int:  0.999996004
p_ni:  0.000003995
p_wrong:  2e-9
Data Source:  BioPlex
SNX27
Tbio
Novelty:  0.02419724
p_int:  0.999984382
p_ni:  0.000015618
Data Source:  BioPlex
ZNF491
Tdark
Family:  TF
Novelty:  4.75862069
p_int:  0.999955661
p_ni:  0.000043943
p_wrong:  3.95e-7
Data Source:  BioPlex
HBM
Tdark
Novelty:  0.02658671
p_int:  0.999874717
p_ni:  0.000124979
p_wrong:  3.04e-7
Data Source:  BioPlex
UQCRQ
Tbio
Novelty:  0.04392627
p_int:  0.999792505
p_ni:  0.000207478
p_wrong:  1.7e-8
Data Source:  BioPlex
TMEM237
Tdark
Novelty:  0.27005874
p_int:  0.999787782
p_ni:  0.000209517
p_wrong:  0.000002701
Data Source:  BioPlex
PCK2
Tbio
Family:  Kinase
Novelty:  0.0035563
p_int:  0.999710039
p_ni:  0.000289914
p_wrong:  4.7e-8
Data Source:  BioPlex
ITPRID2
Tbio
Novelty:  0.07923791
p_int:  0.999661822
p_ni:  0.000328166
p_wrong:  0.000010012
Data Source:  BioPlex
SNW1
Tbio
Novelty:  0.01423797
p_int:  0.999580315
p_ni:  0.000419552
p_wrong:  1.34e-7
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Binding and Uptake of Ligands by Scavenger Receptors (R-HSA-2173782)

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Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Binding and Uptake of Ligands by Scavenger Receptors
Reactome
Cell surface interactions at the vascular wall
Reactome
Hemostasis
Reactome
Scavenging of heme from plasma
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Binding and Uptake of Ligands by Scavenger Receptors
Cell surface interactions at the vascular wall
Hemostasis
Scavenging of heme from plasma
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum non-albumin protein measurement
1
2
2
88.2
blood protein measurement
1
2
2
71.8
heel bone mineral density
1
1
1
61
serum IgG glycosylation measurement
1
1
1
39.5
monocyte percentage of leukocytes
1
1
1
37.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum non-albumin protein measurement
2
88.2
blood protein measurement
2
71.8
heel bone mineral density
1
61
serum IgG glycosylation measurement
1
39.5
monocyte percentage of leukocytes
1
37.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubTator Score 5.28
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title