You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
IGFBP7
Insulin-like growth factor-binding protein 7

Protein Summary
Description
Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion. This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm (PMID:21835307). [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295666
  • ENSP00000295666
  • ENSG00000163453
  • ENST00000514062
  • ENSP00000486293

Symbol
  • MAC25
  • PSF
  • AGM
  • PSF
  • TAF
  • FSTL2
  • IBP-7
  • MAC25
  • IGFBP-7
  • RAMSVPS
  • IGFBP-7v
  • IGFBPRP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
transcription factor perturbation
0.99
protein domain
0.97
PubMedID
0.84
gene perturbation
0.82


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 483.51   (req: < 5)
Gene RIFs: 99   (req: <= 3)
Antibodies: 487   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 483.51   (req: >= 5)
Gene RIFs: 99   (req: > 3)
Antibodies: 487   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (179)
CYR61
Tbio
Novelty:  0.0028995
Score:  0.98
Data Source:  STRINGDB
IGFBP3
Tchem
Novelty:  0.0003776
Score:  0.966
Data Source:  STRINGDB
IGFBP5
Tchem
Novelty:  0.0025185
Score:  0.965
Data Source:  STRINGDB
IGFBP4
Tchem
Novelty:  0.00286837
Score:  0.962
Data Source:  STRINGDB
IGFBP1
Tchem
Novelty:  0.0006975
Score:  0.956
Data Source:  STRINGDB
CST3
Tbio
Novelty:  0.00021856
Score:  0.954
Data Source:  STRINGDB
FN1
Tchem
Novelty:  0.00003647
Score:  0.938
Data Source:  STRINGDB
JUN
Tchem
Family:  TF
Novelty:  0.00006856
Score:  0.936
Data Source:  STRINGDB
TIMP1
Tbio
Family:  Enzyme
Novelty:  0.00020986
Score:  0.935
Data Source:  STRINGDB
IL6
Tclin
Novelty:  0.00001819
Score:  0.934
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (33)
Cellular Senescence (R-HSA-2559583)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
Metabolism of proteins
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
4
3
5
91.1
mean reticulocyte volume
1
1
1
75.6
heel bone mineral density
2
1
2
70.2
hip circumference
1
1
1
58.4
3
3
2
1.1
52.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
5
91.1
mean reticulocyte volume
1
75.6
heel bone mineral density
2
70.2
hip circumference
1
58.4
2
1.1
52.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
insulin like growth factor binding protein 7
VGNC:2984
461304
Macaque
insulin like growth factor binding protein 7
693564
Mouse
MGI:1352480
29817
Rat
RGD:1306201
289560
Dog
insulin like growth factor binding protein 7
VGNC:41908
608559
Species
Name
OMA
EggNOG
Inparanoid
Chimp
insulin like growth factor binding protein 7
Macaque
insulin like growth factor binding protein 7
Mouse
Rat
Dog
insulin like growth factor binding protein 7
Publication Statistics
PubMed Score 483.51
PubMed score by year
PubTator Score 649.51
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title