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Tchem
IGFBP5
Insulin-like growth factor-binding protein 5

Protein Summary
Description
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000233813
  • ENSP00000233813
  • ENSG00000115461

Symbol
  • IBP5
  • IBP5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
1
small molecule perturbation
0.97
transcription factor perturbation
0.96
gene perturbation
0.95
protein domain
0.92


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 424.29   (req: < 5)
Gene RIFs: 107   (req: <= 3)
Antibodies: 395   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 424.29   (req: >= 5)
Gene RIFs: 107   (req: > 3)
Antibodies: 395   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (175)
IGF2
Tbio
Novelty:  0.00021277
p_int:  0.999717518
p_ni:  2.07e-7
p_wrong:  0.000282275
Score:  0.995
Data Source:  BioPlex,Reactome,STRINGDB
IGF1
Tbio
Novelty:  0.00003878
Score:  0.999
Data Source:  Reactome,STRINGDB
FN1
Tchem
Novelty:  0.00003647
Score:  0.982
Data Source:  STRINGDB
PAPPA2
Tbio
Novelty:  0.02135603
Score:  0.975
Data Source:  Reactome,STRINGDB
IGFALS
Tbio
Novelty:  0.0287658
Score:  0.969
Data Source:  Reactome,STRINGDB
IGFBP7
Tbio
Novelty:  0.00249209
Score:  0.965
Data Source:  STRINGDB
PAPPA
Tbio
Novelty:  0.00062817
Score:  0.964
Data Source:  Reactome,STRINGDB
SPP1
Tbio
Novelty:  0.00014418
Score:  0.955
Data Source:  STRINGDB
LTBP1
Tbio
Novelty:  0.00958396
Score:  0.95
Data Source:  STRINGDB
FAM20C
Tbio
Family:  Enzyme
Novelty:  0.00318966
Score:  0.937
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (25)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Post-translational protein phosphorylation
Reactome
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
Post-translational protein phosphorylation
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
corneal topography
1
1
1
34.9
thyroid stimulating hormone measurement
1
1
1
17.8
hormone measurement
1
1
2
13.4
FEV/FEC ratio
1
1
1
12.8
1
1
0
1.3
10.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
corneal topography
1
34.9
thyroid stimulating hormone measurement
1
17.8
hormone measurement
2
13.4
FEV/FEC ratio
1
12.8
0
1.3
10.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
insulin like growth factor binding protein 5
VGNC:1971
740317
Mouse
MGI:96440
16011
Rat
RGD:2876
25285
Dog
insulin like growth factor binding protein 5
VGNC:41906
610316
Horse
insulin like growth factor binding protein 5
VGNC:18974
100034063
Species
Name
OMA
EggNOG
Inparanoid
Chimp
insulin like growth factor binding protein 5
Mouse
Rat
Dog
insulin like growth factor binding protein 5
Horse
insulin like growth factor binding protein 5
Publication Statistics
PubMed Score 424.29
PubMed score by year
PubTator Score 376.65
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title