Tchem IGFBP1 Insulin-like growth factor-binding protein 1

Protein Summary

Description

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration. This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP N-terminal domain and a thyroglobulin type-I domain. The encoded protein, mainly expressed in the liver, circulates in the plasma and binds both insulin-like growth factors (IGFs) I and II, prolonging their half-lives and altering their interaction with cell surface receptors. This protein is important in cell migration and metabolism. Low levels of this protein may be associated with impaired glucose tolerance, vascular disease and hypertension in human patients. [provided by RefSeq, Aug 2017]

Uniprot Accession IDs

• P08833
• A4D2F4
• D3DVL9
• Q8IYP5
• IBP-1

Gene Name

• IGFBP1

Ensembl ID

• ENST00000275525
• ENSP00000275525
• ENSG00000146678

Symbol

• IBP1
• AFBP
• IBP1
• PP12
• IGF-BP25
• hIGFBP-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.92
biological term	0.72
disease	0.69
virus perturbation	0.68
PubMedID	0.67

Protein Classes

PANTHER Classes

Protein / ... / Protease Inhibitor / Insulin-like Growth Factor-binding Protein 1

DTO Classes

Protein / Enzyme Modulator / Protease Inhibitor / Insulin-like Growth Factor-binding Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1512.4   (req: < 5)

Gene RIFs: 242   (req: <= 3)

Antibodies: 600   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1512.4   (req: >= 5)

Gene RIFs: 242   (req: > 3)

Antibodies: 600   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0