Tclin IGF2R Cation-independent mannose-6-phosphate receptor

Protein Summary

Description

Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4. This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma. The orthologous mouse gene is imprinted and shows exclusive expression from the maternal allele; however, imprinting of the human gene may be polymorphic, as only a minority of individuals showed biased expression from the maternal allele (PMID:8267611). [provided by RefSeq, Nov 2015]

Uniprot Accession IDs

• P11717
• Q7Z7G9
• Q96PT5
• CI Man-6-P receptor

Gene Name

• IGF2R

Ensembl ID

• ENST00000356956
• ENSP00000349437
• ENSG00000197081
• ENST00000647592
• ENSP00000497964

Symbol

• MPRI
• MPR1
• MPRI
• CD222
• CIMPR
• M6P-R
• MPR300
• CI-M6PR
• MPR 300
• M6P/IGF2R

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.99
disease perturbation	0.97
cellular component	0.94
virus perturbation	0.94
interacting protein	0.93

Protein Classes

PANTHER Classes

Protein / Receptor / Cation-independent Mannose-6-phosphate Receptor

DTO Classes

Protein / Receptor / Cation-independent Mannose-6-phosphate Receptor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1658   (req: < 5)

Gene RIFs: 134   (req: <= 3)

Antibodies: 642   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1658   (req: >= 5)

Gene RIFs: 134   (req: > 3)

Antibodies: 642   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1