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Tbio
IGF2BP1
Insulin-like growth factor 2 mRNA-binding protein 1

Protein Summary
Description
RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Plays a direct role in the transport and translation of transcripts required for axonal regeneration in adult sensory neurons (By similarity). Regulates localized beta-actin/ACTB mRNA translation, a crucial process for cell polarity, cell migration and neurite outgrowth. Co-transcriptionally associates with the ACTB mRNA in the nucleus. This binding involves a conserved 54-nucleotide element in the ACTB mRNA 3'-UTR, known as the 'zipcode'. The RNP thus formed is exported to the cytoplasm, binds to a motor protein and is transported along the cytoskeleton to the cell periphery. During transport, prevents ACTB mRNA from being transl ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000290341
  • ENSP00000290341
  • ENSG00000159217
  • ENST00000431824
  • ENSP00000389135

Symbol
  • CRDBP
  • VICKZ1
  • ZBP1
  • IMP1
  • ZBP1
  • CRDBP
  • IMP-1
  • CRD-BP
  • VICKZ1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
microRNA
0.95
transcription factor
0.9
hub protein
0.88
kinase perturbation
0.88


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 157.3   (req: < 5)
Gene RIFs: 72   (req: <= 3)
Antibodies: 293   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 157.3   (req: >= 5)
Gene RIFs: 72   (req: > 3)
Antibodies: 293   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (78)
ELAVL2
Tbio
Novelty:  0.00370708
p_int:  0.920864379
p_ni:  0.079135621
Score:  0.532
Data Source:  BioPlex,STRINGDB
RBM47
Tbio
Novelty:  0.04787234
p_int:  0.853034831
p_ni:  0.146965169
Data Source:  BioPlex
RRS1
Tbio
Novelty:  0.01643671
p_int:  0.843672795
p_ni:  0.156327205
Data Source:  BioPlex
MRPS34
Tbio
Novelty:  0.29355603
p_int:  0.841332691
p_ni:  0.158667309
Score:  0.186
Data Source:  BioPlex,STRINGDB
MORN4
Tdark
Novelty:  0.22826325
p_int:  0.790464138
p_ni:  0.209535862
Data Source:  BioPlex
GSPT2
Tchem
Family:  Enzyme
Novelty:  0.08140512
p_int:  0.787314347
p_ni:  0.212685653
Score:  0.638
Data Source:  BioPlex,STRINGDB
IGF2BP3
Tbio
Novelty:  0.00896339
Score:  0.999
Data Source:  STRINGDB
SYNCRIP
Tbio
Novelty:  0.01479381
Score:  0.966
Data Source:  STRINGDB
YBX1
Tbio
Family:  TF
Novelty:  0.00132108
Score:  0.958
Data Source:  STRINGDB
HNRNPU
Tbio
Novelty:  0.00517939
Score:  0.95
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (31)
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA (R-HSA-428359)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA
Reactome
MAPK family signaling cascades
Reactome
MAPK6/MAPK4 signaling
Reactome
Metabolism of RNA
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA
MAPK family signaling cascades
MAPK6/MAPK4 signaling
Metabolism of RNA
Signal Transduction
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (30)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
4
3
1.1
92.4
body mass index
2
2
2
79.7
body height
2
2
2
79.6
alkaline phosphatase measurement
1
1
1
68
BMI-adjusted hip circumference
2
4
4
66.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1.1
92.4
body mass index
2
79.7
body height
2
79.6
alkaline phosphatase measurement
1
68
BMI-adjusted hip circumference
4
66.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
insulin like growth factor 2 mRNA binding protein 1
VGNC:12312
455198
Macaque
insulin like growth factor 2 mRNA binding protein 1
698462
Mouse
MGI:1890357
140486
Rat
RGD:708580
303477
Dog
insulin like growth factor 2 mRNA binding protein 1
VGNC:41898
491064
Species
Name
OMA
EggNOG
Inparanoid
Chimp
insulin like growth factor 2 mRNA binding protein 1
Macaque
insulin like growth factor 2 mRNA binding protein 1
Mouse
Rat
Dog
insulin like growth factor 2 mRNA binding protein 1
Publication Statistics
PubMed Score 157.30
PubMed score by year
PubTator Score 177.11
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title