Tbio IGF2 Insulin-like growth factor II

Protein Summary

Description

The insulin-like growth factors possess growth-promoting activity. Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF-II is influenced by placental lactogen. Also involved in tissue differentiation. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation (By similarity). In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver (Probable). Acts as a ligand for integrin which is required for IGF2 signaling (PubMed:28873464). Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3. This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]

Uniprot Accession IDs

• P01344
• B3KX48
• B7WP08
• C9JAF2
• E3UN45
• P78449
• Q14299
• Q1WM26
• Q9UC68
• Q9UC69
• IGF-II

Gene Name

• IGF2

Ensembl ID

• ENST00000381389
• ENSP00000370796
• ENSG00000167244
• ENST00000381392
• ENSP00000370799
• ENST00000381395
• ENSP00000370802
• ENST00000381406
• ENSP00000370813
• ENST00000416167
• ENSP00000414497
• ENST00000418738
• ENSP00000402047
• ENST00000434045
• ENSP00000391826
• ENST00000641326
• ENSP00000493122

Symbol

• GRDF
• IGF-II
• PP9974
• C11orf43

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
biological term	1
gene perturbation	0.96
PubMedID	0.93
protein domain	0.85

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4969.21   (req: < 5)

Gene RIFs: 592   (req: <= 3)

Antibodies: 544   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4969.21   (req: >= 5)

Gene RIFs: 592   (req: > 3)

Antibodies: 544   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 40

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0