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Tbio
IGF1
Insulin-like growth factor I

Protein Summary
Description
The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation (PubMed:21076856, PubMed:24132240). Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb (By similarity). Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and th ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307046
  • ENSP00000302665
  • ENSG00000017427
  • ENST00000337514
  • ENSP00000337612
  • ENST00000392904
  • ENSP00000376637
  • ENST00000392905
  • ENSP00000376638
  • ENST00000424202
  • ENSP00000416811
  • ENST00000644491
  • ENSP00000494228

Symbol
  • IBP1
  • IGF
  • MGF
  • IGFI
  • IGF-I
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
1
PubMedID
0.93
disease
0.92


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28494.37   (req: < 5)
Gene RIFs: 1510   (req: <= 3)
Antibodies: 1322   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28494.37   (req: >= 5)
Gene RIFs: 1510   (req: > 3)
Antibodies: 1322   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 71
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (682)
IGFBP1
Tchem
Novelty:  0.0006975
Score:  0.999
Data Source:  Reactome,STRINGDB
IGF1R
Tclin
Family:  Kinase
Novelty:  0.00034532
Score:  0.999
Data Source:  Reactome,STRINGDB
IGFBP5
Tchem
Novelty:  0.0025185
Score:  0.999
Data Source:  Reactome,STRINGDB
IGFBP4
Tchem
Novelty:  0.00286837
Score:  0.999
Data Source:  Reactome,STRINGDB
IGFBP3
Tchem
Novelty:  0.0003776
Score:  0.998
Data Source:  Reactome,STRINGDB
IGFBP2
Tchem
Novelty:  0.00083618
Score:  0.998
Data Source:  Reactome,STRINGDB
INSR
Tclin
Family:  Kinase
Novelty:  0.00230617
Score:  0.997
Data Source:  STRINGDB
INS
Tbio
Novelty:  0.00000499
Score:  0.994
Data Source:  STRINGDB
IGFBP6
Tchem
Novelty:  0.00686097
Score:  0.994
Data Source:  Reactome,STRINGDB
VEGFA
Tclin
Novelty:  0.0000378
Score:  0.993
Data Source:  STRINGDB
Nearest Tclin Targets (21)
Explore Nearest Tclin Targets
Pathways (119)
Hemostasis (R-HSA-109582)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hemostasis
Reactome
IGF1R signaling cascade
Reactome
IRS-related events triggered by IGF1R
Reactome
Metabolism of proteins
Reactome
Peptide hormone metabolism
Name
Explore in Pharos
Explore in Source
Hemostasis
IGF1R signaling cascade
IRS-related events triggered by IGF1R
Metabolism of proteins
Peptide hormone metabolism
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (78)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
6
6
95
body height
4
4
4
82.4
sex hormone-binding globulin measurement
4
1
4
77
peak expiratory flow
1
1
1
75.7
systolic blood pressure
1
1
1
64.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
6
95
body height
4
82.4
sex hormone-binding globulin measurement
4
77
peak expiratory flow
1
75.7
systolic blood pressure
1
64.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
insulin like growth factor 1
VGNC:5427
741055
Macaque
insulin like growth factor 1
698444
Mouse
MGI:96432
16000
Rat
RGD:2868
24482
Dog
insulin like growth factor 1
VGNC:41895
610255
Species
Name
OMA
EggNOG
Inparanoid
Chimp
insulin like growth factor 1
Macaque
insulin like growth factor 1
Mouse
Rat
Dog
insulin like growth factor 1
Publication Statistics
PubMed Score 28494.37
PubMed score by year
PubTator Score 14325.24
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title