IFT57
Intraflagellar transport protein 57 homolog
Protein Summary
Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.
- ENST00000264538
- ENSP00000264538
- ENSG00000114446
- DERP8
- ESRRBL1
- HIPPI
- HIPPI
- OFD18
- MHS4R2
- ESRRBL1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0.89 | ||
histone modification site profile | 0.79 | ||
gene perturbation | 0.76 | ||
kinase perturbation | 0.76 | ||
cellular component | 0.73 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 36.8 (req: < 5)
Gene RIFs: 10 (req: <= 3)
Antibodies: 270 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 36.8 (req: >= 5)
Gene RIFs: 10 (req: > 3)
Antibodies: 270 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0