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Tbio
IFT52
Intraflagellar transport protein 52 homolog

Protein Summary
Description
Involved in ciliogenesis as part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia (PubMed:27466190). Required for the anterograde transport of IFT88 (PubMed:27466190). This gene encodes a conserved proline-rich protein that is a component of the intraflagellar transport-B (IFT-B) core complex. The encoded protein is essential for the integrity of the IFT-B core complex, and for biosynthesis and maintenance of cilia. Mutations in this gene are associated with ciliopathy that affects the skeleton. [provided by RefSeq, Oct 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373030
  • ENSP00000362121
  • ENSG00000101052
  • ENST00000373039
  • ENSP00000362130

Symbol
  • C20orf9
  • NGD5
  • NGD2
  • NGD5
  • CGI-53
  • C20orf9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.92
kinase perturbation
0.76
transcription factor perturbation
0.68
cellular component
0.67
cell type or tissue
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.91   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 25   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.91   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 25   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (90)
IFT22
Tbio
Family:  Enzyme
Novelty:  0.18342877
p_int:  0.999999991
p_ni:  9e-9
Score:  0.983
Data Source:  BioPlex,STRINGDB
TTC30A
Tdark
Novelty:  1.41742212
p_int:  0.99999993
p_ni:  7e-8
Score:  0.996
Data Source:  BioPlex,STRINGDB
IFT27
Tbio
Family:  Enzyme
Novelty:  0.05592902
p_int:  0.999999921
p_ni:  7.9e-8
Score:  0.99
Data Source:  BioPlex,STRINGDB
TTC30B
Tbio
Novelty:  0.10944566
p_int:  0.999999812
p_ni:  1.88e-7
Score:  0.998
Data Source:  BioPlex,STRINGDB
ANKRD55
Tbio
Novelty:  0.09730833
p_int:  0.999996401
p_ni:  0.000003598
p_wrong:  1e-9
Score:  0.895
Data Source:  BioPlex,STRINGDB
TFPI2
Tbio
Novelty:  0.00475383
p_int:  0.999983824
p_ni:  0.000016176
Data Source:  BioPlex
IFT57
Tbio
Novelty:  0.03373199
p_int:  0.999967999
p_ni:  0.000031979
p_wrong:  2.2e-8
Score:  0.998
Data Source:  BioPlex,STRINGDB
ARL13B
Tbio
Family:  Enzyme
Novelty:  0.01481674
p_int:  0.999594236
p_ni:  0.000405161
p_wrong:  6.03e-7
Score:  0.908
Data Source:  BioPlex,STRINGDB
ABTB2
Tdark
Novelty:  0.45729157
p_int:  0.999551131
p_ni:  0.000447291
p_wrong:  0.000001578
Data Source:  BioPlex
FGF8
Tbio
Novelty:  0.00155113
p_int:  0.999135873
p_ni:  0.000863968
p_wrong:  1.59e-7
Score:  0.218
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Cilium Assembly (R-HSA-5617833)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cilium Assembly
Reactome
Hedgehog 'off' state
Reactome
Intraflagellar transport
Reactome
Organelle biogenesis and maintenance
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Cilium Assembly
Hedgehog 'off' state
Intraflagellar transport
Organelle biogenesis and maintenance
Signal Transduction
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
1
2
66
2
2
2
65.3
reticulocyte measurement
2
2
2
61.8
mean corpuscular volume
1
1
1
58.4
mean reticulocyte volume
1
1
1
46.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
66
2
65.3
reticulocyte measurement
2
61.8
mean corpuscular volume
1
58.4
mean reticulocyte volume
1
46.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
intraflagellar transport 52
VGNC:6168
738963
Mouse
MGI:2387217
245866
Rat
RGD:1311004
362265
Dog
intraflagellar transport 52
VGNC:41888
610842
Horse
intraflagellar transport 52
VGNC:18962
100055842
Species
Name
OMA
EggNOG
Inparanoid
Chimp
intraflagellar transport 52
Mouse
Rat
Dog
intraflagellar transport 52
Horse
intraflagellar transport 52
Publication Statistics
PubMed Score 20.91
PubMed score by year
PubTator Score 6.54
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title