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Tbio
IFNLR1
Interferon lambda receptor 1

Protein Summary
Description
The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukine 10 receptor, beta ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000327535
  • ENSP00000327824
  • ENSG00000185436
  • ENST00000327575
  • ENSP00000328994
  • ENST00000374418
  • ENSP00000363539
  • ENST00000374421
  • ENSP00000363542

Symbol
  • IL28RA
  • LICR2
  • IFNLR
  • LICR2
  • IL28RA
  • CRF2/12
  • IL-28R1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.77
tissue sample
0.63
transcription factor
0.59
tissue
0.56
microRNA
0.52


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.46   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 220   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.46   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 220   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (134)
JAK1
Tclin
Family:  Kinase
Novelty:  0.00093625
p_int:  0.999980493
p_ni:  0.000019507
Score:  0.992
Data Source:  BioPlex,Reactome,STRINGDB
BTRC
Tbio
Novelty:  0.00293475
p_int:  0.999418858
p_ni:  0.000581142
Data Source:  BioPlex
DPY19L1
Tbio
Family:  Enzyme
Novelty:  0.34765717
p_int:  0.999144192
p_ni:  0.000801147
p_wrong:  0.000054661
Data Source:  BioPlex
TMEM183A
Tdark
Novelty:  0.4017284
p_int:  0.998887307
p_ni:  0.000659176
p_wrong:  0.000453517
Data Source:  BioPlex
FAM3C
Tbio
Novelty:  0.04598347
p_int:  0.997547146
p_ni:  0.002448787
p_wrong:  0.000004067
Data Source:  BioPlex
C1QL1
Tdark
Novelty:  0.11689088
p_int:  0.996111799
p_ni:  0.003882308
p_wrong:  0.000005893
Data Source:  BioPlex
AURKA
Tchem
Family:  Kinase
Novelty:  0.0010868
p_int:  0.993797238
p_ni:  0.006202762
Data Source:  BioPlex
FBXW11
Tbio
Novelty:  0.0715377
p_int:  0.993190186
p_ni:  0.006809813
p_wrong:  1e-9
Data Source:  BioPlex
TMX4
Tbio
Novelty:  0.2628295
p_int:  0.982471348
p_ni:  0.017528652
Data Source:  BioPlex
PNPLA6
Tbio
Family:  Enzyme
Novelty:  0.00295195
p_int:  0.980946792
p_ni:  0.019053208
Data Source:  BioPlex
Nearest Tclin Targets (9)
Explore Nearest Tclin Targets
1 – 5 of 5
IL12B
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  2
IL12A
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  2
IL5
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  2
IL23A
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  2
IL6
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  2
Pathways (39)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-20 family signaling
Reactome
Other interleukin signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-20 family signaling
Other interleukin signaling
Signaling by Interleukins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.2
74.7
type 2 diabetes mellitus
1
1
0
1.1
61.8
C-reactive protein measurement
2
2
2
25.6
psoriasis vulgaris
1
1
0
1.3
16.6
1
1
0
1.1
9.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
74.7
type 2 diabetes mellitus
0
1.1
61.8
C-reactive protein measurement
2
25.6
psoriasis vulgaris
0
1.3
16.6
0
1.1
9.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interferon lambda receptor 1
VGNC:8915
456628
Mouse
MGI:2429859
242700
Rat
RGD:1562689
362628
Dog
interferon lambda receptor 1
VGNC:41881
612276
Horse
interferon lambda receptor 1
VGNC:18955
100057607
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interferon lambda receptor 1
Mouse
Rat
Dog
interferon lambda receptor 1
Horse
interferon lambda receptor 1
Publication Statistics
PubMed Score 79.46
PubMed score by year
PubTator Score 39.87
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title