Tbio IFNGR1 Interferon gamma receptor 1

Protein Summary

Description

Associates with IFNGR2 to form a receptor for the cytokine interferon gamma (IFNG) (PubMed:7615558, PubMed:2971451, PubMed:7617032, PubMed:10986460). Ligand binding stimulates activation of the JAK/STAT signaling pathway (PubMed:7673114). Plays an essential role in the IFN-gamma pathway that is required for the cellular response to infectious agents (PubMed:20015550). This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P15260
• B4DFT7
• E1P587
• Q53Y96
• IFN-gamma receptor 1

Gene Name

• IFNGR1

Ensembl ID

• ENST00000367739
• ENSP00000356713
• ENSG00000027697

Symbol

• CD119
• IFNGR
• IMD27A
• IMD27B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease	0.82
transcription factor perturbation	0.8
phenotype	0.78
hub protein	0.71
PubMedID	0.66

Protein Classes

PANTHER Classes

Protein / Receptor / Cytokine Receptor / Type Ii Cytokine Receptor / Interferon Gamma Receptor 1

Protein / Receptor / Cytokine Receptor / Type I Cytokine Receptor / Interferon Gamma Receptor 1

Protein / Defense/immunity Protein / Interferon Gamma Receptor 1

DTO Classes

Protein / Receptor / Cytokine Receptor / Type Ii Cytokine Receptor / Interferon Gamma Receptor 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 253.88   (req: < 5)

Gene RIFs: 100   (req: <= 3)

Antibodies: 700   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 253.88   (req: >= 5)

Gene RIFs: 100   (req: > 3)

Antibodies: 700   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (154)

Explore Interacting Targets

1 – 10 of 154

• See Interactions on String-DB

MAD2L2

Tbio

Novelty:  0.01091072

p_int:  0.999442161

p_ni:  0.000557839

Data Source:  BioPlex

BMPR1A

Tchem

Family:  Kinase

Novelty:  0.00343928

p_int:  0.969148556

p_ni:  0.030796204

p_wrong:  0.00005524

Score:  0.342

Data Source:  BioPlex,STRINGDB

NDFIP1

Tbio

Novelty:  0.04496467

p_int:  0.963144824

p_ni:  0.036855176

Score:  0.518

Data Source:  BioPlex,STRINGDB

CD320

Tbio

Novelty:  0.01978884

p_int:  0.947081282

p_ni:  0.052867445

p_wrong:  0.000051273

Data Source:  BioPlex

RHOU

Tbio

Family:  Enzyme

Novelty:  0.01456329

p_int:  0.945747576

p_ni:  0.000009858

p_wrong:  0.054242566

Score:  0.195

Data Source:  BioPlex,STRINGDB

IFNG

Tclin

Novelty:  0.00009731

p_int:  0.944341014

p_ni:  0.055658986

Score:  0.997

Data Source:  BioPlex,Reactome,STRINGDB

RAET1E

Tbio

Novelty:  0.01859274

p_int:  0.934968759

p_ni:  0.065031241

Score:  0.172

Data Source:  BioPlex,STRINGDB

SRC

Tclin

Family:  Kinase

Novelty:  0.00008479

p_int:  0.927898739

p_ni:  0.07164351

p_wrong:  0.000457751

Score:  0.296

Data Source:  BioPlex,STRINGDB

SLC9A6

Tbio

Family:  Transporter

Novelty:  0.01410234

p_int:  0.904758279

p_ni:  0.094851757

p_wrong:  0.000389964

Score:  0.556

Data Source:  BioPlex,STRINGDB

FGFR1

Tclin

Family:  Kinase

Novelty:  0.00055714

p_int:  0.895969885

p_ni:  0.102607385

p_wrong:  0.00142273

Score:  0.638

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets (9)

Explore Nearest Tclin Targets

Upstream (5)

Downstream (4)

1 – 5 of 5

IL23A

Tclin

Family:  Other

KEGG Distance:  1

Common Pathways:  6

1: Inflammatory bowel disease (IBD)

2: JAK-STAT signaling pathway

3: Tuberculosis

4: Th17 cell differentiation

more:  2 more common pathways

IL6

Tclin

Family:  Other

KEGG Distance:  1

Common Pathways:  12

1: Inflammatory bowel disease (IBD)

2: Kaposi sarcoma-associated herpesvirus infection

3: Salmonella infection

4: HIF-1 signaling pathway

more:  8 more common pathways

IL12B

Tclin

Family:  Other

KEGG Distance:  1

Common Pathways:  11

1: Inflammatory bowel disease (IBD)

2: JAK-STAT signaling pathway

3: Chagas disease (American trypanosomiasis)

4: Tuberculosis

more:  7 more common pathways

IL12A

Tclin

Family:  Other

KEGG Distance:  1

Common Pathways:  11

1: Inflammatory bowel disease (IBD)

2: JAK-STAT signaling pathway

3: Chagas disease (American trypanosomiasis)

4: Tuberculosis

more:  7 more common pathways

IL5

Tclin

Family:  Other

KEGG Distance:  1

Common Pathways:  5

1: Inflammatory bowel disease (IBD)

2: JAK-STAT signaling pathway

3: Th1 and Th2 cell differentiation

4: Pathways in cancer

5: Cytokine-cytokine receptor interaction

Pathways (86)

Reactome (5)

KEGG (19)

PathwayCommons (7)

WikiPathways (55)

Cytokine Signaling in Immune system (R-HSA-1280215)

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Find Similar Targets

Items per page:

5

1 – 5 of 5

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Interferon Signaling	280 targets	R-HSA-913531
Reactome	Interferon gamma signaling	172 targets	R-HSA-877300
Reactome	Regulation of IFNG signaling	14 targets	R-HSA-877312

Name	Explore in Pharos	Explore in Source
Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Immune System	2246 targets	R-HSA-168256
Interferon Signaling	280 targets	R-HSA-913531
Interferon gamma signaling	172 targets	R-HSA-877300
Regulation of IFNG signaling	14 targets	R-HSA-877312

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (9)

Functions (2)

Components (2)

Processes (5)

Find Similar Targets

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
interferon-gamma receptor activity	Traceable Author Statement (TAS)	ProtInc
cytokine binding	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations (null)

No disease associations found

GWAS Traits (2)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
Oral ulcer	HP_0000155	1	1	0	1.1	85.6
multiple sclerosis	EFO_0003885	3	2	0	1.1	81.7

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
Oral ulcer	HP_0000155	0	1.1	85.6
multiple sclerosis	EFO_0003885	0	1.1	81.7

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Cell membrane
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Glycoprotein
Immunoglobulin domain
Membrane

GWAS Trait Find Similar Targets

No Header	No Header
multiple sclerosis
Oral ulcer

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
cardiovascular system phenotype
cellular phenotype
embryo phenotype
endocrine/exocrine gland phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
integument phenotype
liver/biliary system phenotype

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	interferon gamma receptor 1	VGNC:3122	747276
Mouse	interferon gamma receptor 1	MGI:107655	15979
Rat	interferon gamma receptor 1	RGD:620570	116465
Dog	interferon gamma receptor 1	VGNC:41880	100856077
Horse	interferon gamma receptor 1	VGNC:18952	100073195

Species	Name	OMA	EggNOG	Inparanoid
Chimp	interferon gamma receptor 1
Mouse	interferon gamma receptor 1
Rat	interferon gamma receptor 1
Dog	interferon gamma receptor 1
Horse	interferon gamma receptor 1

Publication Statistics

PubMed Score 253.88

PubMed score by year

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PubTator Score 162.68

PubTator score by year

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Related Publications

Text Mined References (172)

GeneRif Annotations (100)

Items per page:

10

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PMID	Year	Title