Tbio IFNGR1 Interferon gamma receptor 1

Protein Summary

Description

Associates with IFNGR2 to form a receptor for the cytokine interferon gamma (IFNG) (PubMed:7615558, PubMed:2971451, PubMed:7617032, PubMed:10986460). Ligand binding stimulates activation of the JAK/STAT signaling pathway (PubMed:7673114). Plays an essential role in the IFN-gamma pathway that is required for the cellular response to infectious agents (PubMed:20015550). This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P15260
• B4DFT7
• E1P587
• Q53Y96
• IFN-gamma receptor 1

Gene Name

• IFNGR1

Ensembl ID

• ENST00000367739
• ENSP00000356713
• ENSG00000027697

Symbol

• CD119
• IFNGR
• IMD27A
• IMD27B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease	0.82
transcription factor perturbation	0.8
phenotype	0.78
hub protein	0.71
PubMedID	0.66

Protein Classes

PANTHER Classes

Protein / Receptor / Cytokine Receptor / Type Ii Cytokine Receptor / Interferon Gamma Receptor 1

Protein / Receptor / Cytokine Receptor / Type I Cytokine Receptor / Interferon Gamma Receptor 1

Protein / Defense/immunity Protein / Interferon Gamma Receptor 1

DTO Classes

Protein / Receptor / Cytokine Receptor / Type Ii Cytokine Receptor / Interferon Gamma Receptor 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 281.57   (req: < 5)

Gene RIFs: 121   (req: <= 3)

Antibodies: 700   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 281.57   (req: >= 5)

Gene RIFs: 121   (req: > 3)

Antibodies: 700   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0