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Tclin
IFNG
Interferon gamma

Protein Summary
Description
Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000229135
  • ENSP00000229135
  • ENSG00000111537

Symbol
  • IFG
  • IFI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
1
phenotype
1
disease
0.89


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7075.35   (req: < 5)
Gene RIFs: 1371   (req: <= 3)
Antibodies: 2944   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7075.35   (req: >= 5)
Gene RIFs: 1371   (req: > 3)
Antibodies: 2944   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 51
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (549)
IFNGR1
Tbio
Novelty:  0.00417244
p_int:  0.944341014
p_ni:  0.055658986
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
GOPC
Tbio
Novelty:  0.01110168
p_int:  0.920643046
p_ni:  0.079356954
Score:  0.189
Data Source:  BioPlex,STRINGDB
STAT1
Tchem
Family:  TF
Novelty:  0.0003383
Score:  0.989
Data Source:  Reactome,STRINGDB
FOXP3
Tbio
Family:  TF
Novelty:  0.00017205
Score:  0.986
Data Source:  STRINGDB
IRF1
Tbio
Family:  TF
Novelty:  0.00099983
Score:  0.98
Data Source:  STRINGDB
TNF
Tclin
Novelty:  0.00001457
Score:  0.975
Data Source:  STRINGDB
STAT4
Tchem
Family:  TF
Novelty:  0.00251747
Score:  0.971
Data Source:  STRINGDB
IFNGR2
Tbio
Novelty:  0.01304474
Score:  0.968
Data Source:  Reactome,STRINGDB
SOCS3
Tbio
Novelty:  0.00106095
Score:  0.962
Data Source:  Reactome,STRINGDB
RELA
Tchem
Family:  TF
Novelty:  0.0007137
Score:  0.959
Data Source:  STRINGDB
Nearest Tclin Targets (19)
Explore Nearest Tclin Targets
Pathways (97)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Gene expression (Transcription)
Generic Transcription Pathway
Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
3
0
1.2
94
1
1
0
1.1
80.4
platelet crit
1
1
1
70.5
lymphocyte count
2
2
2
67.5
platelet count
1
1
1
57.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
94
0
1.1
80.4
platelet crit
1
70.5
lymphocyte count
2
67.5
platelet count
1
57.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interferon gamma
449517
Macaque
interferon gamma
574282
Mouse
MGI:107656
15978
Rat
RGD:2866
25712
Dog
interferon gamma
VGNC:41879
403801
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interferon gamma
Macaque
interferon gamma
Mouse
Rat
Dog
interferon gamma
Publication Statistics
PubMed Score 7075.35
PubMed score by year
PubTator Score 16981.94
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title