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Tbio
IFNE
Interferon epsilon

Protein Summary
Description
Type I interferon required for maintaining basal levels of IFN-regulated genes, including 2'-5'-oligoadenylate synthetase, IRF7 and ISG15, in the female reproductive tract. Directly mediates protection against viral and bacterial genital infections (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000448696
  • ENSP00000418018
  • ENSG00000184995

Symbol
  • IFNE1
  • IFN-E
  • IFNE1
  • IFNT1
  • INFE1
  • PRO655
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.74
cell line
0.56
disease
0.52
tissue sample
0.42
protein domain
0.41


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.97   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 137   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.97   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (61)
FAM198A
Tdark
Novelty:  0.65293749
p_int:  0.999996292
p_ni:  0.000003558
p_wrong:  1.5e-7
Score:  0.325
Data Source:  BioPlex,STRINGDB
ADGRV1
Tbio
Family:  GPCR
Novelty:  0.01398129
p_int:  0.995843945
p_ni:  0.004156054
p_wrong:  1e-9
Score:  0.179
Data Source:  BioPlex,STRINGDB
FAT4
Tbio
Novelty:  0.01739918
p_int:  0.979584777
p_ni:  0.020415223
Score:  0.181
Data Source:  BioPlex,STRINGDB
BACE2
Tchem
Family:  Enzyme
Novelty:  0.00559862
p_int:  0.975479478
p_ni:  0.024356698
p_wrong:  0.000163824
Score:  0.161
Data Source:  BioPlex,STRINGDB
CD109
Tbio
Novelty:  0.01280272
p_int:  0.964222095
p_ni:  0.035777854
p_wrong:  5.1e-8
Score:  0.166
Data Source:  BioPlex,STRINGDB
NAGLU
Tbio
Family:  Enzyme
Novelty:  0.01033079
p_int:  0.913546502
p_ni:  0.086453498
Score:  0.183
Data Source:  BioPlex,STRINGDB
FAT1
Tbio
Novelty:  0.00340342
p_int:  0.889664611
p_ni:  0.110335389
Score:  0.169
Data Source:  BioPlex,STRINGDB
FRAS1
Tbio
Novelty:  0.02114063
p_int:  0.886423613
p_ni:  0.113576387
Score:  0.156
Data Source:  BioPlex,STRINGDB
LARGE2
Tbio
Family:  Enzyme
Novelty:  0.11843777
p_int:  0.876203679
p_ni:  0.123522219
p_wrong:  0.000274101
Score:  0.179
Data Source:  BioPlex,STRINGDB
IFNAR1
Tclin
Novelty:  0.00175488
Score:  0.888
Data Source:  STRINGDB
Nearest Tclin Targets (17)
Explore Nearest Tclin Targets
1 – 5 of 17
CSF3R
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  2
LEPR
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  2
IL6R
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  2
IL4R
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  2
Pathways (8)
Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
JAK-STAT signaling pathway
KEGG
Cytokine-cytokine receptor interaction
KEGG
RIG-I-like receptor signaling pathway
Name
Explore in Pharos
Explore in Source
JAK-STAT signaling pathway
Cytokine-cytokine receptor interaction
RIG-I-like receptor signaling pathway
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Thyroid preparation use measurement
1
1
1
12.7
neutrophil count
3
1
3
8.5
lymphocyte percentage of leukocytes
1
1
1
8
1
1
1
5.3
neutrophil percentage of leukocytes
1
1
1
4.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Thyroid preparation use measurement
1
12.7
neutrophil count
3
8.5
lymphocyte percentage of leukocytes
1
8
1
5.3
neutrophil percentage of leukocytes
1
4.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interferon epsilon
VGNC:13900
473203
Mouse
MGI:2667156
230405
Rat
RGD:1565065
298225
Dog
interferon epsilon
VGNC:41878
102152624
Horse
interferon epsilon
VGNC:18950
100065067
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interferon epsilon
Mouse
Rat
Dog
interferon epsilon
Horse
interferon epsilon
Publication Statistics
PubMed Score 27.97
PubMed score by year
PubTator Score 9.21
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title