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Tbio
IFNA2
Interferon alpha-2

Protein Summary
Description
Produced by macrophages, IFN-alpha have antiviral activities. This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded protein is a cytokine produced in response to viral infection. Use of the recombinant form of this protein has been shown to be effective in reducing the symptoms and duration of the common cold. [provided by RefSeq, Jun 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380206
  • ENSP00000369554
  • ENSG00000188379

Symbol
  • IFNA2A
  • IFNA2B
  • IFNA2C
  • IFNA
  • INFA2
  • IFNA2B
  • IFN-alphaA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
biological term
0.8
cell type or tissue
0.77
co-expressed gene
0.69
disease
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2841.96   (req: < 5)
Gene RIFs: 83   (req: <= 3)
Antibodies: 988   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2841.96   (req: >= 5)
Gene RIFs: 83   (req: > 3)
Antibodies: 988   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (122)
ISG15
Tbio
Novelty:  0.00203781
p_int:  0.999998155
p_ni:  0.000001742
p_wrong:  1.03e-7
Score:  0.96
Data Source:  BioPlex,STRINGDB
IFNA4
Tbio
Novelty:  0.04421984
p_int:  0.999893357
p_ni:  2e-9
p_wrong:  0.000106642
Score:  0.982
Data Source:  BioPlex,STRINGDB
IFNA5
Tbio
Novelty:  0.02838784
p_int:  0.999497914
p_wrong:  0.000502085
Score:  0.861
Data Source:  BioPlex,STRINGDB
PGLYRP1
Tbio
Novelty:  0.00231527
p_int:  0.992465304
p_ni:  0.007251264
p_wrong:  0.000283432
Score:  0.53
Data Source:  BioPlex,STRINGDB
IFIT3
Tbio
Novelty:  0.00568113
p_int:  0.987570439
p_ni:  0.001102266
p_wrong:  0.011327295
Score:  0.902
Data Source:  BioPlex,STRINGDB
UBR3
Tbio
Family:  Enzyme
Novelty:  0.14930754
p_int:  0.767179917
p_ni:  0.232820083
Score:  0.537
Data Source:  BioPlex,STRINGDB
IFNAR1
Tclin
Novelty:  0.00175488
Score:  0.994
Data Source:  STRINGDB
IFNAR2
Tclin
Novelty:  0.00453303
Score:  0.993
Data Source:  STRINGDB
IRF7
Tbio
Family:  TF
Novelty:  0.0021839
Score:  0.978
Data Source:  STRINGDB
IRF3
Tbio
Family:  TF
Novelty:  0.00099474
Score:  0.956
Data Source:  STRINGDB
Pathways (51)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Hemostasis
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Factors involved in megakaryocyte development and platelet production
Hemostasis
Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
1
2
11.7
lymphocyte percentage of leukocytes
1
1
1
11.3
1
1
0
10.7
7.8
maculopapular eruption
1
1
0
10.7
7.8
response to lamotrigine
1
1
0
10.7
7.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
11.7
lymphocyte percentage of leukocytes
1
11.3
0
10.7
7.8
maculopapular eruption
0
10.7
7.8
response to lamotrigine
0
10.7
7.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interferon alpha 2
VGNC:13898
473198
Macaque
interferon, alpha 2
709948
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interferon alpha 2
Macaque
interferon, alpha 2
Publication Statistics
PubMed Score 2841.96
PubMed score by year
PubTator Score 3033.78
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title