Protein Summary
Produced by macrophages, IFN-alpha have antiviral activities. This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded protein is a cytokine produced in response to viral infection. Use of the recombinant form of this protein has been shown to be effective in reducing the symptoms and duration of the common cold. [provided by RefSeq, Jun 2011]
- ENST00000380206
- ENSP00000369554
- ENSG00000188379
- IFNA2A
- IFNA2B
- IFNA2C
- IFNA
- INFA2
- IFNA2B
- IFN-alphaA
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 0.99 | ||
biological term | 0.8 | ||
cell type or tissue | 0.77 | ||
co-expressed gene | 0.69 | ||
disease | 0.61 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2841.96 (req: < 5)
Gene RIFs: 83 (req: <= 3)
Antibodies: 988 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2841.96 (req: >= 5)
Gene RIFs: 83 (req: > 3)
Antibodies: 988 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 28
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (122)
ISG15
Novelty: 0.00203781
p_int: 0.999998155
p_ni: 0.000001742
p_wrong: 1.03e-7
Score: 0.96
Data Source: BioPlex,STRINGDB
IFNA4
Novelty: 0.04421984
p_int: 0.999893357
p_ni: 2e-9
p_wrong: 0.000106642
Score: 0.982
Data Source: BioPlex,STRINGDB
IFNA5
Novelty: 0.02838784
p_int: 0.999497914
p_wrong: 0.000502085
Score: 0.861
Data Source: BioPlex,STRINGDB
PGLYRP1
Novelty: 0.00231527
p_int: 0.992465304
p_ni: 0.007251264
p_wrong: 0.000283432
Score: 0.53
Data Source: BioPlex,STRINGDB
IFIT3
Novelty: 0.00568113
p_int: 0.987570439
p_ni: 0.001102266
p_wrong: 0.011327295
Score: 0.902
Data Source: BioPlex,STRINGDB
UBR3
Family: Enzyme
Novelty: 0.14930754
p_int: 0.767179917
p_ni: 0.232820083
Score: 0.537
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (18)
Upstream (1)
Downstream (17)
1 – 1 of 1
Pathways (51)
Reactome (10)
KEGG (22)
PathwayCommons (12)
WikiPathways (7)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | DDX58/IFIH1-mediated induction of interferon-alpha/beta | ||||
Reactome | Factors involved in megakaryocyte development and platelet production | ||||
Reactome | Hemostasis | ||||
Reactome | Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Cytokine Signaling in Immune system | ||||
DDX58/IFIH1-mediated induction of interferon-alpha/beta | ||||
Factors involved in megakaryocyte development and platelet production | ||||
Hemostasis | ||||
Immune System | ||||
Viral Interactions (0)
Gene Ontology Terms (31)
Functions (2)
Components (3)
Processes (26)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations (null)
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
neutrophil count | 2 | 1 | 2 | 11.7 | |||||
lymphocyte percentage of leukocytes | 1 | 1 | 1 | 11.3 | |||||
1 | 1 | 0 | 10.7 | 7.8 | |||||
maculopapular eruption | 1 | 1 | 0 | 10.7 | 7.8 | ||||
response to lamotrigine | 1 | 1 | 0 | 10.7 | 7.8 | ||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
neutrophil count | 2 | 11.7 | |||||
lymphocyte percentage of leukocytes | 1 | 11.3 | |||||
0 | 10.7 | 7.8 | |||||
maculopapular eruption | 0 | 10.7 | 7.8 | ||||
response to lamotrigine | 0 | 10.7 | 7.8 | ||||
Find similar targets by:
IDG Resources
Orthologs (2)
1 – 2 of 2
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | interferon alpha 2 | VGNC:13898 | 473198 | |||||
Macaque | interferon, alpha 2 | 709948 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | interferon alpha 2 | |||||
Macaque | interferon, alpha 2 | |||||
Publication Statistics
PubMed Score 2841.96
PubMed score by year
PubTator Score 3033.78
PubTator score by year
Related Publications
Text Mined References (117)
GeneRif Annotations (83)
Items per page:
0 of 0
PMID | Year | Title |
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