Tbio IFNA2 Interferon alpha-2

Protein Summary

Description

Produced by macrophages, IFN-alpha have antiviral activities. This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded protein is a cytokine produced in response to viral infection. Use of the recombinant form of this protein has been shown to be effective in reducing the symptoms and duration of the common cold. [provided by RefSeq, Jun 2011]

Uniprot Accession IDs

• P01563
• H2DF54
• H2DF55
• P01564
• Q14606
• Q6DJX8
• Q96KI6
• IFN-alpha-2

Gene Name

• IFNA2

Ensembl ID

• ENST00000380206
• ENSP00000369554
• ENSG00000188379

Symbol

• IFNA2A
• IFNA2B
• IFNA2C
• IFNA
• INFA2
• IFNA2B
• IFN-alphaA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.99
biological term	0.8
cell type or tissue	0.77
co-expressed gene	0.69
disease	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2841.96   (req: < 5)

Gene RIFs: 83   (req: <= 3)

Antibodies: 988   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2841.96   (req: >= 5)

Gene RIFs: 83   (req: > 3)

Antibodies: 988   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (122)

Explore Interacting Targets

1 – 10 of 122

• See Interactions on String-DB

ISG15

Tbio

Novelty:  0.00203781

p_int:  0.999998155

p_ni:  0.000001742

p_wrong:  1.03e-7

Score:  0.96

Data Source:  BioPlex,STRINGDB

IFNA4

Tbio

Novelty:  0.04421984

p_int:  0.999893357

p_ni:  2e-9

p_wrong:  0.000106642

Score:  0.982

Data Source:  BioPlex,STRINGDB

IFNA5

Tbio

Novelty:  0.02838784

p_int:  0.999497914

p_wrong:  0.000502085

Score:  0.861

Data Source:  BioPlex,STRINGDB

PGLYRP1

Tbio

Novelty:  0.00231527

p_int:  0.992465304

p_ni:  0.007251264

p_wrong:  0.000283432

Score:  0.53

Data Source:  BioPlex,STRINGDB

IFIT3

Tbio

Novelty:  0.00568113

p_int:  0.987570439

p_ni:  0.001102266

p_wrong:  0.011327295

Score:  0.902

Data Source:  BioPlex,STRINGDB

UBR3

Tbio

Family:  Enzyme

Novelty:  0.14930754

p_int:  0.767179917

p_ni:  0.232820083

Score:  0.537

Data Source:  BioPlex,STRINGDB

IFNAR1

Tclin

Novelty:  0.00175488

Score:  0.994

Data Source:  STRINGDB

IFNAR2

Tclin

Novelty:  0.00453303

Score:  0.993

Data Source:  STRINGDB

IRF7

Tbio

Family:  TF

Novelty:  0.0021839

Score:  0.978

Data Source:  STRINGDB

IRF3

Tbio

Family:  TF

Novelty:  0.00099474

Score:  0.956

Data Source:  STRINGDB

Nearest Tclin Targets (18)

Explore Nearest Tclin Targets

Upstream (1)

Downstream (17)

1 – 1 of 1

TLR9

Tclin

Family:  Other

KEGG Distance:  2

Common Pathways:  4

1: Toll-like receptor signaling pathway

2: Tuberculosis

3: Measles

4: Herpes simplex virus 1 infection

Pathways (51)

Reactome (10)

KEGG (22)

PathwayCommons (12)

WikiPathways (7)

Cytokine Signaling in Immune system (R-HSA-1280215)

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Find Similar Targets

Items per page:

5

1 – 5 of 10

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Reactome	DDX58/IFIH1-mediated induction of interferon-alpha/beta	77 targets	R-HSA-168928
Reactome	Factors involved in megakaryocyte development and platelet production	139 targets	R-HSA-983231
Reactome	Hemostasis	666 targets	R-HSA-109582
Reactome	Immune System	2246 targets	R-HSA-168256

Name	Explore in Pharos	Explore in Source
Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
DDX58/IFIH1-mediated induction of interferon-alpha/beta	77 targets	R-HSA-168928
Factors involved in megakaryocyte development and platelet production	139 targets	R-HSA-983231
Hemostasis	666 targets	R-HSA-109582
Immune System	2246 targets	R-HSA-168256

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (31)

Functions (2)

Components (3)

Processes (26)

Find Similar Targets

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
cytokine activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
type I interferon receptor binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations (null)

No disease associations found

GWAS Traits (6)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 6

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
neutrophil count	EFO_0004833	2	1	2		11.7
lymphocyte percentage of leukocytes	EFO_0007993	1	1	1		11.3
epilepsy	EFO_0000474	1	1	0	10.7	7.8
maculopapular eruption	EFO_1001253	1	1	0	10.7	7.8
response to lamotrigine	EFO_0007661	1	1	0	10.7	7.8

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 6

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
neutrophil count	EFO_0004833	2		11.7
lymphocyte percentage of leukocytes	EFO_0007993	1		11.3
epilepsy	EFO_0000474	0	10.7	7.8
maculopapular eruption	EFO_1001253	0	10.7	7.8
response to lamotrigine	EFO_0007661	0	10.7	7.8

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Antiviral defense
Complete proteome
Cytokine
Direct protein sequencing
Disulfide bond
Glycoprotein
Pharmaceutical
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
epilepsy
lymphocyte percentage of leukocytes
maculopapular eruption
neutrophil count
neutrophil percentage of leukocytes
response to lamotrigine

IDG Resources

No IDG generated resources found

Orthologs (2)

1 – 2 of 2

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	interferon alpha 2	VGNC:13898	473198
Macaque	interferon, alpha 2		709948

Species	Name	OMA	EggNOG	Inparanoid
Chimp	interferon alpha 2
Macaque	interferon, alpha 2

Publication Statistics

PubMed Score 2841.96

PubMed score by year

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PubTator Score 3033.78

PubTator score by year

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Related Publications

Text Mined References (117)

GeneRif Annotations (83)

Items per page:

10

0 of 0

PMID	Year	Title