Tbio IFNA10 Interferon alpha-10

Protein Summary

Description

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. This gene encodes a protein that belongs to the type I interferon family of proteins, and is located in a cluster of alpha interferon genes on chromosome 9. Interferons are small regulatory molecules that function in cell signaling in response to viruses and other pathogens or tumor cells. This gene is intronless and the encoded protein is secreted. [provided by RefSeq, Aug 2013]

Uniprot Accession IDs

• P01566
• Q5VV13
• IFN-alpha-10

Gene Name

• IFNA10

Ensembl ID

• ENST00000357374
• ENSP00000369566
• ENSG00000186803

Symbol

• IFN-alphaC

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.91
biological process	0.82
cell line	0.56
virus perturbation	0.55
pathway	0.52

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.62   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 174   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.62   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 174   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (3)

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (81)

Explore Interacting Targets

1 – 10 of 81

• See Interactions on String-DB

ISG15

Tbio

Novelty:  0.00203781

p_int:  0.999863743

p_ni:  0.000136255

p_wrong:  2e-9

Score:  0.228

Data Source:  BioPlex,STRINGDB

IFIT1

Tbio

Novelty:  0.00562299

p_int:  0.999111822

p_ni:  0.000697794

p_wrong:  0.000190384

Score:  0.354

Data Source:  BioPlex,STRINGDB

UBR3

Tbio

Family:  Enzyme

Novelty:  0.14930754

p_int:  0.980595177

p_ni:  0.019404823

Score:  0.188

Data Source:  BioPlex,STRINGDB

IFNA7

Tdark

Novelty:  0.14618009

Score:  0.927

Data Source:  STRINGDB

IFNA16

Tdark

Novelty:  0.1709941

Score:  0.919

Data Source:  STRINGDB

IRF7

Tbio

Family:  TF

Novelty:  0.0021839

Score:  0.917

Data Source:  STRINGDB

IFNA17

Tbio

Novelty:  0.0030696

Score:  0.917

Data Source:  STRINGDB

IFNAR1

Tclin

Novelty:  0.00175488

Score:  0.917

Data Source:  STRINGDB

IFNA4

Tbio

Novelty:  0.04421984

Score:  0.912

Data Source:  STRINGDB

IFNAR2

Tclin

Novelty:  0.00453303

Score:  0.912

Data Source:  STRINGDB

Nearest Tclin Targets (18)

Explore Nearest Tclin Targets

Upstream (1)

Downstream (17)

1 – 1 of 1

TLR9

Tclin

Family:  Other

KEGG Distance:  2

Common Pathways:  4

1: Toll-like receptor signaling pathway

2: Tuberculosis

3: Measles

4: Herpes simplex virus 1 infection

Pathways (90)

Reactome (10)

KEGG (22)

PathwayCommons (12)

WikiPathways (46)

Cytokine Signaling in Immune system (R-HSA-1280215)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Reactome	DDX58/IFIH1-mediated induction of interferon-alpha/beta	77 targets	R-HSA-168928
Reactome	Factors involved in megakaryocyte development and platelet production	139 targets	R-HSA-983231
Reactome	Hemostasis	666 targets	R-HSA-109582
Reactome	Immune System	2246 targets	R-HSA-168256

Name	Explore in Pharos	Explore in Source
Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
DDX58/IFIH1-mediated induction of interferon-alpha/beta	77 targets	R-HSA-168928
Factors involved in megakaryocyte development and platelet production	139 targets	R-HSA-983231
Hemostasis	666 targets	R-HSA-109582
Immune System	2246 targets	R-HSA-168256

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (16)

Functions (2)

Components (2)

Processes (12)

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10

1 – 2 of 2

GO Term	Evidence	Assigned by
cytokine activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
type I interferon receptor binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations (null)

No disease associations found

GWAS Traits (0)

No GWAS traits found

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Antiviral defense
Complete proteome
Cytokine
Direct protein sequencing
Disulfide bond
Polymorphism
Reference proteome
Secreted
Signal

IDG Resources

No IDG generated resources found

Orthologs

No orthologs found

Publication Statistics

PubMed Score 18.62

PubMed score by year

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PubTator Score 16.94

PubTator score by year

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Related Publications

Text Mined References (20)

GeneRif Annotations (6)

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0 of 0

PMID	Year	Title