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Tbio
IFNA1
Interferon alpha-1/13

Protein Summary
Description
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. The protein encoded by this gene is produced by macrophages and has antiviral activity. This gene is intronless and the encoded protein is secreted. [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000276927
  • ENSP00000276927
  • ENSG00000197919
  • ENST00000449498
  • ENSP00000394494
  • ENSG00000233816

Symbol
  • IFL
  • IFN
  • IFNA@
  • IFNA13
  • IFN-ALPHA
  • IFN-alphaD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.64
cell line
0.46
phenotype
0.42
gene perturbation
0.36
transcription factor
0.36


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11014.59   (req: < 5)
Gene RIFs: 226   (req: <= 3)
Antibodies: 823   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11014.59   (req: >= 5)
Gene RIFs: 226   (req: > 3)
Antibodies: 823   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (167)
IFNA6
Tbio
Novelty:  0.06253956
p_int:  0.999999739
p_ni:  1.3e-8
p_wrong:  2.48e-7
Score:  0.836
Data Source:  BioPlex,STRINGDB
IFNA21
Tbio
Novelty:  0.00581034
p_int:  0.99999957
p_ni:  4.25e-7
p_wrong:  6e-9
Score:  0.829
Data Source:  BioPlex,STRINGDB
IFNA17
Tbio
Novelty:  0.0030696
p_int:  0.999999298
p_ni:  2e-9
p_wrong:  7e-7
Score:  0.245
Data Source:  BioPlex,STRINGDB
IFNA14
Tbio
Novelty:  0.17853653
p_int:  0.999997627
p_ni:  7.9e-8
p_wrong:  0.000002294
Score:  0.843
Data Source:  BioPlex,STRINGDB
IFNA4
Tbio
Novelty:  0.04421984
p_int:  0.999995794
p_ni:  0.000004206
Data Source:  BioPlex
ISG15
Tbio
Novelty:  0.00203781
p_int:  0.999989149
p_ni:  0.000010844
p_wrong:  8e-9
Score:  0.924
Data Source:  BioPlex,STRINGDB
IFNA5
Tbio
Novelty:  0.02838784
p_int:  0.999876354
p_ni:  0.000123646
Data Source:  BioPlex
TOX4
Tbio
Family:  TF
Novelty:  0.02486844
p_int:  0.981455961
p_ni:  0.014710585
p_wrong:  0.003833453
Data Source:  BioPlex
IFNA8
Tbio
Novelty:  0.0310922
p_int:  0.980803479
p_ni:  0.019196511
p_wrong:  1e-8
Data Source:  BioPlex
HCCS
Tbio
Family:  Enzyme
Novelty:  0.0022585
p_int:  0.937458918
p_ni:  0.062533216
p_wrong:  0.000007866
Score:  0.535
Data Source:  BioPlex,STRINGDB
Pathways (88)
Cytokine Signaling in Immune system (R-HSA-1280215)

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Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Hemostasis
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Factors involved in megakaryocyte development and platelet production
Hemostasis
Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
1
2
11.7
neutrophil count
2
1
2
11.7
lymphocyte percentage of leukocytes
1
1
1
11.3
lymphocyte percentage of leukocytes
1
1
1
11.3
1
1
0
10.7
7.8
Items per page:
1 – 5 of 12
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
11.7
neutrophil count
2
11.7
lymphocyte percentage of leukocytes
1
11.3
lymphocyte percentage of leukocytes
1
11.3
0
10.7
7.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 11014.59
PubMed score by year
PubTator Score 6289.26
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title