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Tbio
IFIT1
Interferon-induced protein with tetratricopeptide repeats 1

Protein Summary
Description
Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses. This gene encodes a protein containing tetratricopeptide repeats that was originally identified as induced upon treatment with interferon. T ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371804
  • ENSP00000360869
  • ENSG00000185745
  • ENST00000546318
  • ENSP00000441968

Symbol
  • G10P1
  • IFI56
  • IFNAI1
  • ISG56
  • C56
  • P56
  • G10P1
  • IFI56
  • ISG56
  • IFI-56
  • IFIT-1
  • IFNAI1
  • RNM561
  • IFI-56K
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
gene perturbation
0.97
small molecule perturbation
0.96
transcription factor perturbation
0.91
protein domain
0.85


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 222.6   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 230   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 222.6   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 230   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0