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Tbio
IFI30
Gamma-interferon-inducible lysosomal thiol reductase

Protein Summary
Description
Lysosomal thiol reductase that can reduce protein disulfide bonds. May facilitate the complete unfolding of proteins destined for lysosomal degradation. Plays an important role in antigen processing. Facilitates the generation of MHC class II-restricted epitodes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds (By similarity). Facilitates also MHC class I-restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T-cells or crosspresentation (By similarity). The protein encoded by this gene is a lysosomal thiol reductase that at low pH can reduce protein disulfide bonds. The enzyme is expressed constitutively in antigen-presenting cells and induced by gamma-interferon in other cell types. This enzyme has an important role in MHC class II-restricted antigen processing. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000407280
  • ENSP00000384886
  • ENSG00000216490

Symbol
  • GILT
  • IP30
  • GILT
  • IP30
  • IP-30
  • IFI-30
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.91
kinase perturbation
0.88
disease perturbation
0.87
PubMedID
0.84
transcription factor perturbation
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130.49   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 150   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130.49   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 150   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (214)
DAPK1
Tchem
Family:  Kinase
Novelty:  0.0031894
p_int:  0.999999945
p_ni:  4.6e-8
p_wrong:  9e-9
Score:  0.385
Data Source:  BioPlex,STRINGDB
TTC31
Tdark
Novelty:  2.10386254
p_int:  0.999999937
p_ni:  5.8e-8
p_wrong:  4e-9
Score:  0.226
Data Source:  BioPlex,STRINGDB
DEPDC1B
Tbio
Novelty:  0.06124069
p_int:  0.999999875
p_ni:  4.3e-8
p_wrong:  8.1e-8
Score:  0.303
Data Source:  BioPlex,STRINGDB
UBE3B
Tbio
Family:  Enzyme
Novelty:  0.06274049
p_int:  0.999992956
p_ni:  9.49e-7
p_wrong:  0.000006095
Score:  0.226
Data Source:  BioPlex,STRINGDB
TJP1
Tbio
Novelty:  0.00040365
p_int:  0.999978054
p_ni:  0.000021946
Data Source:  BioPlex
GTPBP2
Tbio
Novelty:  0.10282876
p_int:  0.999773524
p_ni:  0.000226476
Score:  0.226
Data Source:  BioPlex,STRINGDB
TJP2
Tbio
Novelty:  0.00446681
p_int:  0.999724405
p_ni:  0.000275595
Data Source:  BioPlex
BRCA1
Tchem
Novelty:  0.00011146
p_int:  0.999668114
p_ni:  0.000103511
p_wrong:  0.000228375
Score:  0.187
Data Source:  BioPlex,STRINGDB
FAM122B
Tdark
Novelty:  1.90668674
p_int:  0.999242756
p_ni:  0.00075683
p_wrong:  4.14e-7
Data Source:  BioPlex
FAM120A
Tbio
Novelty:  0.1054654
p_int:  0.999120834
p_ni:  0.000879166
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interferon Signaling
Reactome
Interferon gamma signaling
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Cytokine Signaling in Immune system
Immune System
Interferon Signaling
Interferon gamma signaling
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (34)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
7
13
19
97.9
waist-hip ratio
3
10
11
97.8
serum alanine aminotransferase measurement
2
2
1
9.8
89.5
3
3
0
1.1
89.5
visceral adipose tissue measurement
2
2
2
88.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
19
97.9
waist-hip ratio
11
97.8
serum alanine aminotransferase measurement
1
9.8
89.5
0
1.1
89.5
visceral adipose tissue measurement
2
88.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
IFI30, lysosomal thiol reductase
VGNC:10248
748630
Mouse
MGI:2137648
65972
Rat
RGD:1310758
290644
Dog
IFI30, lysosomal thiol reductase
VGNC:41871
476669
Horse
IFI30, lysosomal thiol reductase [Source:HGNC Symbol;Acc:HGNC:5398]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
IFI30, lysosomal thiol reductase
Mouse
Rat
Dog
IFI30, lysosomal thiol reductase
Horse
IFI30, lysosomal thiol reductase [Source:HGNC Symbol;Acc:HGNC:5398]
Publication Statistics
PubMed Score 130.49
PubMed score by year
PubTator Score 42.73
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title