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Tdark
IFFO2
Intermediate filament family orphan 2

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000455833
  • ENSP00000387941
  • ENSG00000169991
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.91
transcription factor perturbation
0.74
transcription factor binding site profile
0.7
tissue sample
0.62
microRNA
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.56   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 29   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.56   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 29   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (27)
XRCC4
Tbio
Novelty:  0.00305644
p_int:  0.999999793
p_ni:  1.98e-7
p_wrong:  9e-9
Score:  0.519
Data Source:  BioPlex,STRINGDB
PPP1R13B
Tbio
Novelty:  0.03903985
p_int:  0.999998673
p_ni:  0.000001319
p_wrong:  8e-9
Data Source:  BioPlex
FGFR2
Tclin
Family:  Kinase
Novelty:  0.00066613
p_int:  0.999977701
p_ni:  0.00002229
p_wrong:  9e-9
Score:  0.188
Data Source:  BioPlex,STRINGDB
MRTO4
Tbio
Novelty:  0.06676322
Score:  0.626
Data Source:  STRINGDB
AKR7A2
Tbio
Family:  Enzyme
Novelty:  0.00917827
Score:  0.626
Data Source:  STRINGDB
WDR75
Tbio
Novelty:  0.09443914
Score:  0.619
Data Source:  STRINGDB
TAGAP
Tbio
Family:  Enzyme
Novelty:  0.04450409
Score:  0.582
Data Source:  STRINGDB
CASTOR2
Tbio
Novelty:  0.3255398
Score:  0.518
Data Source:  STRINGDB
MTIF3
Tbio
Novelty:  0.04751341
Score:  0.517
Data Source:  STRINGDB
AKR7A3
Tbio
Family:  Enzyme
Novelty:  0.10681298
Score:  0.516
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
brain measurement
1
1
0
6.4
32.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
brain measurement
0
6.4
32.3
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
intermediate filament family orphan 2
100612108
Macaque
intermediate filament family orphan 2
106995162
Mouse
MGI:2140675
212632
Cow
intermediate filament family orphan 2
788579
Pig
intermediate filament family orphan 2
100737107
Species
Name
OMA
EggNOG
Inparanoid
Chimp
intermediate filament family orphan 2
Macaque
intermediate filament family orphan 2
Mouse
Cow
intermediate filament family orphan 2
Pig
intermediate filament family orphan 2
Publication Statistics
PubMed Score 0.56
PubMed score by year
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Related Publications
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0 of 0
PMID
Year
Title