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Tdark
IFFO1
Intermediate filament family orphan 1

Protein Summary
Description
This gene is a member of the intermediate filament family. Intermediate filaments are proteins which are primordial components of the cytoskeleton and nuclear envelope. The proteins encoded by the members of this gene family are evolutionarily and structurally related but have limited sequence homology, with the exception of the central rod domain. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336604
  • ENSP00000337593
  • ENSG00000010295
  • ENST00000356896
  • ENSP00000349364
  • ENST00000396840
  • ENSP00000380052
  • ENST00000487279
  • ENSP00000432493

Symbol
  • IFFO
  • IFFO
  • HOM-TES-103
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.92
disease perturbation
0.79
kinase perturbation
0.71
cell type or tissue
0.7
tissue sample
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.98   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 60   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.98   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 60   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (41)
XRCC4
Tbio
Novelty:  0.00305644
p_int:  0.999999076
p_ni:  9.23e-7
p_wrong:  1e-9
Score:  0.295
Data Source:  BioPlex,STRINGDB
FSD2
Tbio
Novelty:  0.1302271
p_int:  0.999997524
p_ni:  0.000002476
Data Source:  BioPlex
PPP1R13B
Tbio
Novelty:  0.03903985
p_int:  0.999995668
p_ni:  0.000004332
Data Source:  BioPlex
ZNF574
Tdark
Family:  TF
Novelty:  2.72596185
p_int:  0.999396365
p_ni:  0.000603597
p_wrong:  3.8e-8
Data Source:  BioPlex
RBSN
Tbio
Novelty:  0.0046123
p_int:  0.993149162
p_ni:  0.006849804
p_wrong:  0.000001034
Score:  0.161
Data Source:  BioPlex,STRINGDB
SNX32
Tdark
Novelty:  0.66136036
p_int:  0.986410087
p_ni:  0.013584987
p_wrong:  0.000004926
Score:  0.161
Data Source:  BioPlex,STRINGDB
P4HA2
Tbio
Family:  Enzyme
Novelty:  0.02097718
p_int:  0.98615929
p_ni:  0.013833605
p_wrong:  0.000007105
Data Source:  BioPlex
RPL28
Tbio
Novelty:  0.03136035
p_int:  0.97688217
p_ni:  0.023110821
p_wrong:  0.000007009
Data Source:  BioPlex
TPTE2
Tbio
Family:  Enzyme
Novelty:  0.04710658
p_int:  0.974929454
p_ni:  0.008207225
p_wrong:  0.016863322
Data Source:  BioPlex
IL23A
Tclin
Novelty:  0.00440193
p_int:  0.965149062
p_ni:  0.021408688
p_wrong:  0.01344225
Score:  0.323
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
1
1
1
67.1
mean corpuscular volume
1
1
1
57.3
red blood cell distribution width
1
1
1
56.8
triglyceride measurement
1
1
1
53.3
heel bone mineral density
2
2
2
47.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
1
67.1
mean corpuscular volume
1
57.3
red blood cell distribution width
1
56.8
triglyceride measurement
1
53.3
heel bone mineral density
2
47.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
intermediate filament family orphan 1
VGNC:5425
466936
Macaque
intermediate filament family orphan 1
712900
Mouse
MGI:2444516
320678
Rat
RGD:1308257
362437
Dog
intermediate filament family orphan 1
VGNC:41870
486725
Species
Name
OMA
EggNOG
Inparanoid
Chimp
intermediate filament family orphan 1
Macaque
intermediate filament family orphan 1
Mouse
Rat
Dog
intermediate filament family orphan 1
Publication Statistics
PubMed Score 2.98
PubMed score by year
PubTator Score 1.25
PubTator score by year
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Related Publications
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PMID
Year
Title