Tbio IER3 Radiation-inducible immediate-early gene IEX-1

Protein Summary

Description

May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A-PPP2R5C holoenzyme. Acts also as an ERK downstream effector mediating survival. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. This gene functions in the protection of cells from Fas- or tumor necrosis factor type alpha-induced apoptosis. Partially degraded and unspliced transcripts are found after virus infection in vitro, but these transcripts are not found in vivo and do not generate a valid protein. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P46695
• Q5SU30
• Q92691
• Q93044

Gene Name

• IER3

Ensembl ID

• ENST00000259874
• ENSP00000259874
• ENSG00000137331
• ENST00000383560
• ENSP00000373054
• ENSG00000206478
• ENST00000416884
• ENSP00000406245
• ENSG00000227231
• ENST00000435856
• ENSP00000412283
• ENSG00000235030
• ENST00000439190
• ENSP00000397956
• ENSG00000237155
• ENST00000450236
• ENSP00000398139
• ENSG00000230128

Symbol

• DIF2
• IEX1
• PRG1
• DIF2
• IEX1
• PRG1
• DIF-2
• GLY96
• IEX-1
• IEX-1L

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.99
kinase perturbation	0.97
gene perturbation	0.96
transcription factor binding site profile	0.91
small molecule perturbation	0.84

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 159.02   (req: < 5)

Gene RIFs: 45   (req: <= 3)

Antibodies: 151   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 159.02   (req: >= 5)

Gene RIFs: 45   (req: > 3)

Antibodies: 151   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0